{"title":"关于3-羧基茴香醇的脱羧。","authors":"A M Marshall, M Hirst","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>3-Carboxysalsolinol (14C-COOH) was prepared from DOPA (1-14C). Both in vitro and in vivo studies were conducted to examine the possibility that this amino-acid tetrahydroisoquinoline is converted to salsolinol in a parallel manner to the formation of dopamine from its amino-acid precursor. The results showed that this is not so for DOPA is decarboxylated far more readily than is 3-carboxysalsolinol. Small quantities of carbon dioxide (14C) are liberated from 3-carboxysalsolinol (14C-COOH), but this may reflect non-enzymatic decarboxylation.</p>","PeriodicalId":22076,"journal":{"name":"Substance and alcohol actions/misuse","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Concerning the decarboxylation of 3-carboxysalsolinol.\",\"authors\":\"A M Marshall, M Hirst\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>3-Carboxysalsolinol (14C-COOH) was prepared from DOPA (1-14C). Both in vitro and in vivo studies were conducted to examine the possibility that this amino-acid tetrahydroisoquinoline is converted to salsolinol in a parallel manner to the formation of dopamine from its amino-acid precursor. The results showed that this is not so for DOPA is decarboxylated far more readily than is 3-carboxysalsolinol. Small quantities of carbon dioxide (14C) are liberated from 3-carboxysalsolinol (14C-COOH), but this may reflect non-enzymatic decarboxylation.</p>\",\"PeriodicalId\":22076,\"journal\":{\"name\":\"Substance and alcohol actions/misuse\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Substance and alcohol actions/misuse\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Substance and alcohol actions/misuse","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Concerning the decarboxylation of 3-carboxysalsolinol.
3-Carboxysalsolinol (14C-COOH) was prepared from DOPA (1-14C). Both in vitro and in vivo studies were conducted to examine the possibility that this amino-acid tetrahydroisoquinoline is converted to salsolinol in a parallel manner to the formation of dopamine from its amino-acid precursor. The results showed that this is not so for DOPA is decarboxylated far more readily than is 3-carboxysalsolinol. Small quantities of carbon dioxide (14C) are liberated from 3-carboxysalsolinol (14C-COOH), but this may reflect non-enzymatic decarboxylation.
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