胰岛素和胰高血糖素对(-)-羟基柠檬酸培养的肝细胞从乙酸合成脂肪酸的影响。

Endokrinologie Pub Date : 1982-06-01

A C Beynen, M J Geelen

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摘要

(——)-羟基柠檬酸盐是众所周知的柠檬酸裂解酶抑制剂(EC 4.1.3.8)。在分离的肝细胞中，它抑制葡萄糖合成脂肪酸，但不影响醋酸合成脂肪酸。在它存在的情况下，胰岛素刺激和胰高血糖素抑制标记醋酸纳入脂肪酸。这是两种激素直接影响醋酸合成脂肪酸的证据。

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Effects of insulin and glucagon on fatty acid synthesis from acetate by hepatocytes incubated with (--)-hydroxycitrate.

(--)-Hydroxycitrate is a well-known inhibitor of the citrate cleavage enzyme (EC 4.1.3.8). In isolated hepatocytes it inhibits fatty acid synthesis from glucose, but it does not affect fatty acid synthesis from acetate. In its presence, insulin stimulates and glucagon inhibits incorporation of labelled acetate into fatty acids. This is evidence that both hormones directly influence fatty acid synthesis from acetate.

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Endokrinologie

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