{"title":"人造玻璃纤维对健康影响的研究现状。","authors":"P Gross","doi":"10.1007/BF00378073","DOIUrl":null,"url":null,"abstract":"<p><p>Concerns engendered by inappropriate extrapolation from rat intracavitary cancer experiments stimulated the initiation of new retrospective and prospective epidemiologic studies of man-made vitreous fibers (MMVF). The results of these new studies have confirmed those of previous investigations that MMVF exposure had not caused an increased risk to develop lung cancer or nonmalignant respiratory disease. In contrast to the high pathogenic potential of MMVF (thin long fibers) when injected into the body cavities of rats, the pulmonary reaction of rodents inhaling such fibers has been that of a nuisance-type dust. The results of new experimental inhalation studies have not yet been published. In vitro studies have demonstrated cytotoxicity of thin long MMVF. Although there is a parallelism between the in vitro cytotoxicity results of MMVF and those of the in vivo intracavitary carcinogenesis studies with the same fibers, it is difficult to attach significance to this parallelism insofar as man is concerned because the rat intracavitary carcinogenesis results have no relevance to man.</p>","PeriodicalId":13761,"journal":{"name":"International Archives of Occupational and Environmental Health","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00378073","citationCount":"5","resultStr":"{\"title\":\"Man-made vitreous fibers: present status of research on health effects.\",\"authors\":\"P Gross\",\"doi\":\"10.1007/BF00378073\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Concerns engendered by inappropriate extrapolation from rat intracavitary cancer experiments stimulated the initiation of new retrospective and prospective epidemiologic studies of man-made vitreous fibers (MMVF). The results of these new studies have confirmed those of previous investigations that MMVF exposure had not caused an increased risk to develop lung cancer or nonmalignant respiratory disease. In contrast to the high pathogenic potential of MMVF (thin long fibers) when injected into the body cavities of rats, the pulmonary reaction of rodents inhaling such fibers has been that of a nuisance-type dust. The results of new experimental inhalation studies have not yet been published. In vitro studies have demonstrated cytotoxicity of thin long MMVF. Although there is a parallelism between the in vitro cytotoxicity results of MMVF and those of the in vivo intracavitary carcinogenesis studies with the same fibers, it is difficult to attach significance to this parallelism insofar as man is concerned because the rat intracavitary carcinogenesis results have no relevance to man.</p>\",\"PeriodicalId\":13761,\"journal\":{\"name\":\"International Archives of Occupational and Environmental Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"1982-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF00378073\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Archives of Occupational and Environmental Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/BF00378073\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Archives of Occupational and Environmental Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/BF00378073","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Man-made vitreous fibers: present status of research on health effects.
Concerns engendered by inappropriate extrapolation from rat intracavitary cancer experiments stimulated the initiation of new retrospective and prospective epidemiologic studies of man-made vitreous fibers (MMVF). The results of these new studies have confirmed those of previous investigations that MMVF exposure had not caused an increased risk to develop lung cancer or nonmalignant respiratory disease. In contrast to the high pathogenic potential of MMVF (thin long fibers) when injected into the body cavities of rats, the pulmonary reaction of rodents inhaling such fibers has been that of a nuisance-type dust. The results of new experimental inhalation studies have not yet been published. In vitro studies have demonstrated cytotoxicity of thin long MMVF. Although there is a parallelism between the in vitro cytotoxicity results of MMVF and those of the in vivo intracavitary carcinogenesis studies with the same fibers, it is difficult to attach significance to this parallelism insofar as man is concerned because the rat intracavitary carcinogenesis results have no relevance to man.
期刊介绍:
International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors.
In addition, all papers should be based on present-day standards and relate to:
-Clinical and epidemiological studies on morbidity and mortality
-Clinical epidemiological studies on the parameters relevant to the estimation of health risks
-Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects.
-Methods for studying the topics mentioned above.