尼古丁能增强戊巴比妥钠而不是乙醇诱导的睡眠。

Substance and alcohol actions/misuse Pub Date : 1983-01-01

A T Modak, B E Alderete

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摘要

尼古丁以剂量依赖的方式增强戊巴比妥钠诱导的睡眠时间，而不是乙醇。甲胺，一种尼古丁受体拮抗剂，阻断了尼古丁引起的睡眠时间的增加。阿托品本身减少了睡眠时间，但没有改变尼古丁的效果。假设中枢和外周烟碱受体在增强戊巴比妥钠诱导的睡眠时间中起重要作用。

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Nicotine potentiates sodium pentobarbital but not ethanol induced sleep.

Nicotine potentiates, in a dose dependent manner, the sleep time induced by sodium pentobarbital but not by ethanol. Mecamylamine, a nicotinic receptor antagonist, blocked the nicotine induced increase in sleep time. Atropine itself reduced sleep time but did not change the nicotine effect. It is hypothesized that the central and the peripheral nicotinic receptors play an important role in potentiating sodium pentobarbital induced sleep time.

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Substance and alcohol actions/misuse

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