大鼠心脏毒蕈碱受体对慢性乙醇摄入的抵抗。

Substance and alcohol actions/misuse Pub Date : 1984-01-01
P Posner, S P Baker, K N Prestwich, R G Carpentier
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引用次数: 0

摘要

长期饮酒与心肌病和心律失常的发生有关。这些疾病可能继发于自主神经系统流出物的改变。这项研究观察了心肌细胞对氨甲酰胆碱(CBL)的反应性和毒蕈碱受体浓度的变化。研究人员从雄性龙-埃文斯大鼠身上切除心脏,分别喂食乙醇(E)和对照(C)液体食物。乙醇饮食提供35-39%的卡路里作为乙醇。研究是在8-10周或18-20周后进行的。采用(-)-[3H]苯基喹啉酸(QNB)测定心室毒蕈碱受体。这些研究显示,摄入E 8-10周和18-20周后,毒菌碱受体浓度和[3H]QNB结合的解离常数没有显著差异。电生理研究显示,8-10周和18-20周后,E组和C组对CBL的变时性反应无显著差异。在18-20周时,E组和C组辅助起搏器细胞对CBL的反应性无差异。这些数据表明,慢性E摄入长达20周不影响心脏毒蕈碱受体浓度或胆碱能反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The resistance of the cardiac muscarinic receptor to chronic ethanol ingestion in the rat.

The chronic consumption of alcohol has been correlated with the development of cardiomyopathy and dysrhythmias. These disorders may be secondary to changes in the outflow of the autonomic nervous system. This study looked at the changes in cardiac cell responsiveness to carbamylcholine (CBL) and the concentration of muscarinic receptors. The studies were carried out on hearts excised from male Long-Evans hooded rats, pair-fed on ethanol (E) or control (C) liquid diet. The ethanol diet supplied 35-39% of calories as ethanol. The studies were carried out after 8-10 wks or 18-20 wks on the diet. Ventricular muscarinic receptors were measured using (-)-[3H]quinuclidinyl benzilate (QNB). These studies showed no significant difference in muscarinic receptor concentration or the dissociation constant for [3H]QNB binding after 8-10 wks or 18-20 wks of E ingestion. Electrophysiologic studies of chronotropic responsiveness to CBL showed no significant difference between the E and C groups after 8-10 wks or 18-20 wks. The responsiveness of subsidiary pacemaker cells to CBL was not different between E and C groups at 18-20 wks. These data indicate that chronic E ingestion for up to 20 wks did not effect the cardiac muscarinic receptor concentration or cholinergic response.

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