{"title":"活化蛋白C在凝血酶诱导的血小板聚集中的作用。","authors":"E Novoa Santander, L Derpich Miranda","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Platelets aggregate with thrombin-free activated protein C in concentrations higher than physiological levels. Aggregation was dependent on an intact release mechanism since inhibition of aggregation occurred with adenosine or EDTA. However, activated protein C reduced the sensitivity of platelets to aggregate in the presence of thrombin. Probably, activated protein C competes for membrane sites sensitive to thrombin.</p>","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 2","pages":"161-4"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of activated protein C on platelet aggregation induced by thrombin.\",\"authors\":\"E Novoa Santander, L Derpich Miranda\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Platelets aggregate with thrombin-free activated protein C in concentrations higher than physiological levels. Aggregation was dependent on an intact release mechanism since inhibition of aggregation occurred with adenosine or EDTA. However, activated protein C reduced the sensitivity of platelets to aggregate in the presence of thrombin. Probably, activated protein C competes for membrane sites sensitive to thrombin.</p>\",\"PeriodicalId\":7131,\"journal\":{\"name\":\"Acta physiologica latino americana\",\"volume\":\"33 2\",\"pages\":\"161-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta physiologica latino americana\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica latino americana","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of activated protein C on platelet aggregation induced by thrombin.
Platelets aggregate with thrombin-free activated protein C in concentrations higher than physiological levels. Aggregation was dependent on an intact release mechanism since inhibition of aggregation occurred with adenosine or EDTA. However, activated protein C reduced the sensitivity of platelets to aggregate in the presence of thrombin. Probably, activated protein C competes for membrane sites sensitive to thrombin.
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