Chromosomal abnormalities in leukemia.

Since the discovery that human somatic cells contain 46 chromosomes, a number of diseases have been found to be related to abnormalities in chromosome structure or number. Many of these chromosome abnormalities are found in hematologic disorders, which have been called clinicocytogenetic syndromes. Cytogenetic studies in these disorders have proved to be helpful in both diagnosis and predicting response to therapy.