{"title":"谷氨酰胺诱导不同酒精动机大鼠脑氨基酸神经递质含量的变化。","authors":"Ostrovsky SYu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The 10-day administration of glutamine (500 mg/kg per day) with the drinking water to adult albino rats with different alcohol motivation resulted in a significant increase in the content of glutamate, GABA and taurine in the brain. The level of glycine was decreased only in the ethanol-preferring animals. The results obtained are discussed in terms of a possible role of the amino acid neurotransmitters, particularly GABA, in the antialcoholic action of glutamine.</p>","PeriodicalId":22076,"journal":{"name":"Substance and alcohol actions/misuse","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glutamine-induced alterations in the content of brain amino acid neurotransmitters in rats with different alcohol motivation.\",\"authors\":\"Ostrovsky SYu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The 10-day administration of glutamine (500 mg/kg per day) with the drinking water to adult albino rats with different alcohol motivation resulted in a significant increase in the content of glutamate, GABA and taurine in the brain. The level of glycine was decreased only in the ethanol-preferring animals. The results obtained are discussed in terms of a possible role of the amino acid neurotransmitters, particularly GABA, in the antialcoholic action of glutamine.</p>\",\"PeriodicalId\":22076,\"journal\":{\"name\":\"Substance and alcohol actions/misuse\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Substance and alcohol actions/misuse\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Substance and alcohol actions/misuse","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Glutamine-induced alterations in the content of brain amino acid neurotransmitters in rats with different alcohol motivation.
The 10-day administration of glutamine (500 mg/kg per day) with the drinking water to adult albino rats with different alcohol motivation resulted in a significant increase in the content of glutamate, GABA and taurine in the brain. The level of glycine was decreased only in the ethanol-preferring animals. The results obtained are discussed in terms of a possible role of the amino acid neurotransmitters, particularly GABA, in the antialcoholic action of glutamine.
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