片剂中的乳糖:功能，关键材料属性，应用，修改和协同加工辅料

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2023-09-01 DOI:10.1016/j.drudis.2023.103696

Chuting Shi , Haiyue Zhao , Ying Fang , Lan Shen , Lijie Zhao

{"title":"片剂中的乳糖:功能，关键材料属性，应用，修改和协同加工辅料","authors":"Chuting Shi , Haiyue Zhao , Ying Fang , Lan Shen , Lijie Zhao","doi":"10.1016/j.drudis.2023.103696","DOIUrl":null,"url":null,"abstract":"<div><p>Lactose is one of the most widespread excipients used in the pharmaceutical industry. Because of its water solubility and acceptable flowability, lactose is generally added into tablet formulation to improve wettability and undesirable flowability. Based on Quality by Design, a better understanding of the critical material attributes (CMAs) of raw materials is beneficial in guiding the improvement of tablet quality and the development of lactose. Additionally, the modifications and co-processing of lactose can introduce more-desirable characteristics to the resulting particles. This review focuses on the functionality, CMAs, applications, modifications and co-processing of lactose in tablets.</p></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"28 9","pages":"Article 103696"},"PeriodicalIF":6.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Lactose in tablets: Functionality, critical material attributes, applications, modifications and co-processed excipients\",\"authors\":\"Chuting Shi , Haiyue Zhao , Ying Fang , Lan Shen , Lijie Zhao\",\"doi\":\"10.1016/j.drudis.2023.103696\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Lactose is one of the most widespread excipients used in the pharmaceutical industry. Because of its water solubility and acceptable flowability, lactose is generally added into tablet formulation to improve wettability and undesirable flowability. Based on Quality by Design, a better understanding of the critical material attributes (CMAs) of raw materials is beneficial in guiding the improvement of tablet quality and the development of lactose. Additionally, the modifications and co-processing of lactose can introduce more-desirable characteristics to the resulting particles. This review focuses on the functionality, CMAs, applications, modifications and co-processing of lactose in tablets.</p></div>\",\"PeriodicalId\":301,\"journal\":{\"name\":\"Drug Discovery Today\",\"volume\":\"28 9\",\"pages\":\"Article 103696\"},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S135964462300212X\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S135964462300212X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 4

摘要

乳糖是制药工业中使用最广泛的辅料之一。由于其水溶性和可接受的流动性，乳糖通常被添加到片剂配方中，以改善润湿性和不理想的流动性。在设计品质的基础上，更好地了解原料的关键物质属性(CMAs)，有助于指导片剂质量的提高和乳糖的开发。此外，乳糖的改性和协同加工可以为所得颗粒引入更理想的特性。本文综述了乳糖片剂的功能、cma、应用、修饰和协同加工。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lactose in tablets: Functionality, critical material attributes, applications, modifications and co-processed excipients

查看原文本刊更多论文

Lactose in tablets: Functionality, critical material attributes, applications, modifications and co-processed excipients

Lactose is one of the most widespread excipients used in the pharmaceutical industry. Because of its water solubility and acceptable flowability, lactose is generally added into tablet formulation to improve wettability and undesirable flowability. Based on Quality by Design, a better understanding of the critical material attributes (CMAs) of raw materials is beneficial in guiding the improvement of tablet quality and the development of lactose. Additionally, the modifications and co-processing of lactose can introduce more-desirable characteristics to the resulting particles. This review focuses on the functionality, CMAs, applications, modifications and co-processing of lactose in tablets.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.