Catalytic-Amount Oxidant for Ester-Directed Pd-Catalyzed Olefination

The development of cost-effective and efficient oxidation strategies employing catalytic amounts of oxidants, as alternatives to excessive and expensive metal–salt oxidants, remains highly significant in the field of organic synthesis. Herein, we report a weakly coordinating ester-directed Pd-catalyzed olefination enabled by catalytic amounts of oxidant, providing a cleaner and more practical strategy for synthetic applications. Desired yields could be obtained either by extending the reaction time or by adding an additional catalytic amount of Ag₂CO₃. This oxidation system not only successfully achieved gram-scale reaction amplification, but also significantly reduced the amount of palladium catalyst while maintaining high reaction efficiency.