M Arevalo Turrubiarte, H Rideout, A D Whetton, N Geifman, S K Armstrong
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Chronic renal disease detection developments with future potential to improve veterinary clinical practice.
Chronic Kidney Disease (CKD) is a major global human and veterinary health concern. Novel blood and urine biomarkers currently offer significant opportunities to advance early diagnosis, prognosis, and clinical outcomes. Adopting a translational medicine approach, we summarise research performed to date on CKD biomarkers in humans and relate these findings to companion animal CKD biomarker research. Emerging candidates, including microRNAs and multiprotein measurements for diagnostic signatures, are also considered. We discuss the potential complementarity offered by multi-omic approaches and Artificial Intelligence (AI) driven diagnostic algorithm generation for the understanding of CKD pathogenesis in dogs and cats.
期刊介绍:
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.