Rafael Matos Vieira Gordilho, Nilo Jorge Carvalho Leão Barreto, Felipe Pinho E Albuquerque Silva, João Victor Pereira Gonzalez, Nathalia Pedreira Santos de Lemos, Kenzo Ogasawara Donato, Paula Alana Morais Seixas, Gabriela Nunes E Brito, Henrique Brasileiro Terceiro, Felipe Pereira Garrido Pazos, Rodrigo Barbosa Freire Silvão, Cristina Salles
{"title":"不宁腿综合征与勃起功能障碍之间的关系：系统回顾和荟萃分析。","authors":"Rafael Matos Vieira Gordilho, Nilo Jorge Carvalho Leão Barreto, Felipe Pinho E Albuquerque Silva, João Victor Pereira Gonzalez, Nathalia Pedreira Santos de Lemos, Kenzo Ogasawara Donato, Paula Alana Morais Seixas, Gabriela Nunes E Brito, Henrique Brasileiro Terceiro, Felipe Pereira Garrido Pazos, Rodrigo Barbosa Freire Silvão, Cristina Salles","doi":"10.1007/s41105-026-00674-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in patients with RLS. We followed the PRISMA 2020 protocol.</p><p><strong>Results: </strong>This systematic review included a total sample of 33,740 participants. Patients with RLS had 70% higher odds of ED compared with non-RLS controls (OR = 1.70; 95% CI: 1.52-1.91; <i>p</i> < 0.001; I² = 0%). The group with severe RLS had lower odds of ED than the mild-moderate RLS group (OR = 0.67; 95% CI: 0.53-0.84; <i>p</i> = 0.0005). The RLS group presented increased odds of severe ED compared with non-RLS controls (OR = 4.51; 95% CI: 1.52-13.33; <i>p</i> = 0.006; I² = 0%), but no significant difference compared with controls for mild or moderate ED (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Individuals with RLS have 70% higher odds of ED compared with non-RLS controls. Severe ED was more frequent among patients with RLS, while no significant differences were observed for mild or moderate ED. These findings support ED screening in patients with RLS.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at https://doi.org/10.1007/s41105-026-00674-4.</p>","PeriodicalId":21896,"journal":{"name":"Sleep and Biological Rhythms","volume":"24 4","pages":"451-459"},"PeriodicalIF":2.0000,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619993/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between restless legs syndrome and erectile dysfunction: a systematic review and meta-analysis.\",\"authors\":\"Rafael Matos Vieira Gordilho, Nilo Jorge Carvalho Leão Barreto, Felipe Pinho E Albuquerque Silva, João Victor Pereira Gonzalez, Nathalia Pedreira Santos de Lemos, Kenzo Ogasawara Donato, Paula Alana Morais Seixas, Gabriela Nunes E Brito, Henrique Brasileiro Terceiro, Felipe Pereira Garrido Pazos, Rodrigo Barbosa Freire Silvão, Cristina Salles\",\"doi\":\"10.1007/s41105-026-00674-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in patients with RLS. We followed the PRISMA 2020 protocol.</p><p><strong>Results: </strong>This systematic review included a total sample of 33,740 participants. Patients with RLS had 70% higher odds of ED compared with non-RLS controls (OR = 1.70; 95% CI: 1.52-1.91; <i>p</i> < 0.001; I² = 0%). The group with severe RLS had lower odds of ED than the mild-moderate RLS group (OR = 0.67; 95% CI: 0.53-0.84; <i>p</i> = 0.0005). The RLS group presented increased odds of severe ED compared with non-RLS controls (OR = 4.51; 95% CI: 1.52-13.33; <i>p</i> = 0.006; I² = 0%), but no significant difference compared with controls for mild or moderate ED (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Individuals with RLS have 70% higher odds of ED compared with non-RLS controls. Severe ED was more frequent among patients with RLS, while no significant differences were observed for mild or moderate ED. These findings support ED screening in patients with RLS.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at https://doi.org/10.1007/s41105-026-00674-4.</p>\",\"PeriodicalId\":21896,\"journal\":{\"name\":\"Sleep and Biological Rhythms\",\"volume\":\"24 4\",\"pages\":\"451-459\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2026-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619993/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sleep and Biological Rhythms\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s41105-026-00674-4\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2026/10/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep and Biological Rhythms","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s41105-026-00674-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/10/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Association between restless legs syndrome and erectile dysfunction: a systematic review and meta-analysis.
Objective: To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls.
Methods: We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in patients with RLS. We followed the PRISMA 2020 protocol.
Results: This systematic review included a total sample of 33,740 participants. Patients with RLS had 70% higher odds of ED compared with non-RLS controls (OR = 1.70; 95% CI: 1.52-1.91; p < 0.001; I² = 0%). The group with severe RLS had lower odds of ED than the mild-moderate RLS group (OR = 0.67; 95% CI: 0.53-0.84; p = 0.0005). The RLS group presented increased odds of severe ED compared with non-RLS controls (OR = 4.51; 95% CI: 1.52-13.33; p = 0.006; I² = 0%), but no significant difference compared with controls for mild or moderate ED (p > 0.05).
Conclusion: Individuals with RLS have 70% higher odds of ED compared with non-RLS controls. Severe ED was more frequent among patients with RLS, while no significant differences were observed for mild or moderate ED. These findings support ED screening in patients with RLS.
Supplementary information: The online version contains supplementary material available at https://doi.org/10.1007/s41105-026-00674-4.
期刊介绍：
Sleep and Biological Rhythms is a quarterly peer-reviewed publication dealing with medical treatments relating to sleep. The journal publishies original articles, short papers, commentaries and the occasional reviews. In scope the journal covers mechanisms of sleep and wakefullness from the ranging perspectives of basic science, medicine, dentistry, pharmacology, psychology, engineering, public health and related branches of the social sciences
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