肝移植后序贯乘客淋巴细胞综合征和皮肤显性急性移植物抗宿主病。

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2026-09-29 eCollection Date: 2026-10-01 DOI:10.14309/crj.0000000000002329

Urveesh Sharma, Yash Shah, Manesh Kumar Gangwani, Mary K Rude, Matthew Deneke

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引用次数: 0

摘要

乘客淋巴细胞综合征（PLS）和急性移植物抗宿主病（aGVHD）都是由供体淋巴细胞引起的，但它们是不同的免疫介导的并发症，很少在同一受体中依次记录。我们报告了一名63岁的女性，她在轻微ABO血型系统不匹配的肝移植术后第1天出现严重的溶血性贫血，与PLS一致，8周后皮肤活检和外周血嵌合支持皮肤显性aGVHD。早期诊断和使用大剂量皮质类固醇治疗可迅速改善病情。本病例强调了这些并发症可依次发生，并强调了器官受累模式和早期活检对预后的重要性。

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Sequential Passenger Lymphocyte Syndrome and Skin-Predominant Acute Graft-vs-Host Disease After Liver Transplantation.

Passenger lymphocyte syndrome (PLS) and acute graft-vs-host disease (aGVHD) both arise from donor lymphocytes but represent distinct immune-mediated complications rarely documented sequentially in the same recipient. We report a 63-year-old woman who developed severe hemolytic anemia on postoperative day 1 after minor ABO blood group system-mismatched liver transplantation, consistent with PLS, followed 8 weeks later by skin-predominant aGVHD supported by skin biopsy and peripheral blood chimerism. Early diagnosis and treatment with high-dose corticosteroids led to rapid improvement. This case highlights that these complications can occur in sequence and underscores the prognostic importance of organ involvement pattern and early biopsy.

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.