通过可编程微环境调制加速伤口愈合的超声响应水凝胶。

IF 5.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2026-10-19 Epub Date: 2026-09-28 DOI:10.1021/acsabm.6c01430

Yue Ming, Weixing Chen, Bo Jia, Min Sun, Jianzhong Du

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引用次数: 0

摘要

涉及持续炎症和纤维化的伤口愈合是由活性氧（ROS）和yes相关蛋白（YAP）驱动的，通常导致疤痕。研制了一种聚乙烯醇/海藻酸盐超声响应水凝胶，其基质中含有游离的表没食子儿茶素没食子酸酯（EGCG），水凝胶网络中嵌入EGCG-维替泊芬（VP）纳米颗粒。游离EGCG释放迅速，而EGCG- vp纳米颗粒释放是由超声波触发的。在体外，该系统减少ROS约69%。Western blot显示α-平滑肌肌动蛋白减少~ 71%，YAP减少~ 47%。在体内，它能促进大鼠伤口愈合。该系统实现了伤口微环境的可编程调制。

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Ultrasound-Responsive Hydrogels for Accelerated Wound Healing through Programmable Microenvironment Modulation

Wound healing involving persistent inflammation and fibrosis is driven by reactive oxygen species (ROS) and Yes-associated protein (YAP), often leading to scars. A polyvinyl alcohol/alginate ultrasound-responsive hydrogel was developed, containing free epigallocatechin gallate (EGCG) in the matrix and EGCG-verteporfin (VP) nanoparticles embedded in the hydrogel network. Free EGCG is released rapidly, whereas EGCG-VP nanoparticles release is triggered by ultrasound. In vitro, this system reduced ROS by ∼69%. Western blot revealed ∼71% reduction in α-smooth muscle actin and ∼47% in YAP. In vivo, it promoted wound closure in rats. This system enables programmable modulation of the wound microenvironment.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.