烯丙雌醇或己烯雌酚对成年期大鼠肝脏微粒体酶活性的影响。

Medical biology Pub Date : 1986-01-01

G Csaba, S Szeberényi, O Dobozy

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引用次数: 0

摘要

新生大鼠单次接受类固醇(烯丙雌醇或己烯雌酚)治疗不会改变肝微粒体(细胞色素P-450)酶系统的后期活性，但会抑制6周龄时另一种类固醇(睾酮)的诱导作用。这表明类似激素印记的机制在酶的情况下也起作用。

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Influence of single neonatal treatment with allylestrenol or diethylstilbestrol on microsomal enzyme activity of rat liver in adulthood.

A single neonatal treatment of rats with a steroid (allylestrenol or diethylstilbestrol) did not alter the later activity of the hepatic microsomal (cytochrome P-450) enzyme system, but inhibited the inducer action of another steroid (testosterone) administered at the age of six weeks. This suggests that a hormonal imprinting-like mechanism also operates in the case of enzymes.

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来源期刊

Medical biology

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