Evrim Anik, Cherie Armour, Else Guthrie, James D Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Betty Raman, Olivia C Leavy, Matthew Richardson, Omer Elneima, Hamish J C McAuley, Amisha Singapuri, Marco Sereno, Ruth M Saunders, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Ewen M Harrison, Annemarie B Docherty, Nazir I Lone, Jennifer K Quint, Louise V Wain, Rachael A Evans, Christopher E Brightling, Robert M West, Max Henderson
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Psychological trauma was assessed using the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) 5 and 12 months after discharge. We used log binomial regression to identify risk factors for probable PTSD.</p><p><strong>Results: </strong>We describe 1565 study participants discharged from hospital between February 2020 and March 2021 following an admission for COVID-19. Most were male (61.3%), White (77.4%) and from more deprived areas (62%). Of these, 15% had probable PTSD (PCL-5 ≥34) at 5 months which was associated with being 18 to 50 years old (risk ratio: 3.0 (2.1- 4.3), <i>p</i> < 0.001), lower income (e.g. <£19,001, risk ratio 2.1, 95% CI: 1.5 - 2.8, <i>p</i> < 0.001), longer admission and a history of depression or anxiety. Out of 236, 136 (57.6%) with probable PTSD at 5 months still had probable PTSD at 12 months. Persistence was associated with intensive care unit (ICU) admission (risk ratio 1.3, 95% CI 1.1-1.6, <i>p</i> < 0.001) and higher anxiety and PCL-5 scores at 5 months.</p><p><strong>Conclusions: </strong>Probable PTSD was common 5 months after admission for COVID-19 and was associated with lower socioeconomic status, longer admission and previous depression or anxiety. 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Psychological trauma was assessed using the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) 5 and 12 months after discharge. We used log binomial regression to identify risk factors for probable PTSD.</p><p><strong>Results: </strong>We describe 1565 study participants discharged from hospital between February 2020 and March 2021 following an admission for COVID-19. Most were male (61.3%), White (77.4%) and from more deprived areas (62%). Of these, 15% had probable PTSD (PCL-5 ≥34) at 5 months which was associated with being 18 to 50 years old (risk ratio: 3.0 (2.1- 4.3), <i>p</i> < 0.001), lower income (e.g. <£19,001, risk ratio 2.1, 95% CI: 1.5 - 2.8, <i>p</i> < 0.001), longer admission and a history of depression or anxiety. Out of 236, 136 (57.6%) with probable PTSD at 5 months still had probable PTSD at 12 months. 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引用次数: 0
摘要
背景：COVID-19住院的心理后果，如创伤后应激障碍（PTSD），研究不足。目的：了解2019冠状病毒病（COVID-19）患者出院后心理创伤症状的流行情况及其危险因素。方法：我们使用来自英国医院COVID-19后出院成人住院后COVID-19（磷素- covid）研究的数据。出院后5个月和12个月使用DSM-5 （PCL-5）创伤后应激障碍检查表评估心理创伤。我们使用对数二项回归来确定可能的PTSD的危险因素。结果：我们描述了1565名研究参与者在2020年2月至2021年3月因COVID-19入院后出院。大多数是男性（61.3%），白人（77.4%）和来自较贫困地区（62%）。其中，15%的患者在5个月时可能患有PTSD (PCL-5≥34)，这与18至50岁（风险比：3.0 (2.1- 4.3),p < 0.001）、收入较低（例如p < 0.001）、住院时间较长以及有抑郁或焦虑史有关。在236人中，有136人（57.6%）在5个月时可能患有PTSD，在12个月时仍然可能患有PTSD。持续治疗与重症监护病房（ICU）入院（风险比1.3,95% CI 1.1-1.6, p < 0.001）以及5个月时更高的焦虑和PCL-5评分相关。结论：新冠肺炎患者入院后5个月可能出现PTSD，与社会经济地位较低、入院时间较长、既往抑郁或焦虑相关。超过一半的患者在12个月时仍有症状，与ICU住院和更高的5个月PCL-5评分相关。
Probable post-traumatic stress disorder following discharge from hospital with COVID-19: prospective cohort study.
Background: The psychological consequences of hospital admission for COVID-19, such as post-traumatic stress disorder (PTSD), are under-researched.
Aims: To describe the prevalence of, and risk factors for, psychological trauma symptoms in COVID-19 patients discharged from hospital.
Method: We used data from the Post-Hospitalisation COVID-19 (PHOSP-COVID) study of adults discharged from UK hospitals after COVID-19. Psychological trauma was assessed using the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) 5 and 12 months after discharge. We used log binomial regression to identify risk factors for probable PTSD.
Results: We describe 1565 study participants discharged from hospital between February 2020 and March 2021 following an admission for COVID-19. Most were male (61.3%), White (77.4%) and from more deprived areas (62%). Of these, 15% had probable PTSD (PCL-5 ≥34) at 5 months which was associated with being 18 to 50 years old (risk ratio: 3.0 (2.1- 4.3), p < 0.001), lower income (e.g. <£19,001, risk ratio 2.1, 95% CI: 1.5 - 2.8, p < 0.001), longer admission and a history of depression or anxiety. Out of 236, 136 (57.6%) with probable PTSD at 5 months still had probable PTSD at 12 months. Persistence was associated with intensive care unit (ICU) admission (risk ratio 1.3, 95% CI 1.1-1.6, p < 0.001) and higher anxiety and PCL-5 scores at 5 months.
Conclusions: Probable PTSD was common 5 months after admission for COVID-19 and was associated with lower socioeconomic status, longer admission and previous depression or anxiety. Over half remained symptomatic at 12 months, associated with ICU admission and higher 5-month PCL-5 scores.
期刊介绍：
Announcing the launch of BJPsych Open, an exciting new open access online journal for the publication of all methodologically sound research in all fields of psychiatry and disciplines related to mental health. BJPsych Open will maintain the highest scientific, peer review, and ethical standards of the BJPsych, ensure rapid publication for authors whilst sharing research with no cost to the reader in the spirit of maximising dissemination and public engagement. Cascade submission from BJPsych to BJPsych Open is a new option for authors whose first priority is rapid online publication with the prestigious BJPsych brand. Authors will also retain copyright to their works under a creative commons license.
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