多氟查尔酮与羟胺的反应及随后的分子内环化

IF 1.6 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2026-07-01 Epub Date: 2026-06-23 DOI:10.1016/j.jfluchem.2026.110591

I.N. Gavrilov, N.A. Orlova, P.A. Demakov, T.V. Rybalova

引用次数: 0

摘要

根据查尔酮的结构和反应条件不同，多氟查尔酮与盐酸羟胺反应生成肟、3-羟胺肟、二氢喹啉和苯并恶唑衍生物。后两种结构类型是通过取代羰基旁边的全氟苯基环上的邻氟原子而形成的分子内环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Reactions of polyfluorinated chalcones with hydroxylamine and subsequent intramolecular cyclization

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Reactions of polyfluorinated chalcones with hydroxylamine and subsequent intramolecular cyclization

Polyfluorinated chalcones react with hydroxylamine hydrochloride to form oximes, 3-hydroxylaminooximes, dihydroquinoline and benzisoxazole derivatives, depending on the chalcone structure and the reaction conditions. The last two structure types are formed as a result of intramolecular cyclization by replacing the ortho-fluorine atom in the perfluoro phenyl ring next to the carbonyl group.

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.