Subhash Kheruka, Sana Al-Rashdi, Naema Al-Maymani, Anas Al-Balushi, Tasnim Al-Raii, Noura Al-Makhmari, Vipin Jayakrishnan, Anjali Jain, Khulood Al-Riyami, Rashid Al-Sukaiti
{"title":"经认证的68Ge PET圆柱体模体中的不均匀性：标准化质量保证的含义。","authors":"Subhash Kheruka, Sana Al-Rashdi, Naema Al-Maymani, Anas Al-Balushi, Tasnim Al-Raii, Noura Al-Makhmari, Vipin Jayakrishnan, Anjali Jain, Khulood Al-Riyami, Rashid Al-Sukaiti","doi":"10.2967/jnmt.125.271634","DOIUrl":null,"url":null,"abstract":"<p><p>Quantitative PET imaging depends critically on the accuracy of system normalization and uniformity calibration. We report a manufacturing defect in a certified RadQual <sup>68</sup>Ge PET cylinder phantom (BMCY68-2030A-03), a standard reference used for normalization and daily quality control in Siemens Biograph Vision scanners. A localized hot spot was identified within the phantom, producing integral uniformity greater than 8.5% (acceptance limit ≤5%). The nonuniformity was intrinsic to the phantom material and rendered it unsuitable for quantitative use. This finding underscores the importance of independent acceptance testing of long-lived <sup>68</sup>Ge standards before clinical deployment to prevent calibration bias and ensure reliable SUV quantification.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nonuniformity in a Certified <sup>68</sup>Ge PET Cylinder Phantom: Implications for Normalization Quality Assurance.\",\"authors\":\"Subhash Kheruka, Sana Al-Rashdi, Naema Al-Maymani, Anas Al-Balushi, Tasnim Al-Raii, Noura Al-Makhmari, Vipin Jayakrishnan, Anjali Jain, Khulood Al-Riyami, Rashid Al-Sukaiti\",\"doi\":\"10.2967/jnmt.125.271634\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Quantitative PET imaging depends critically on the accuracy of system normalization and uniformity calibration. We report a manufacturing defect in a certified RadQual <sup>68</sup>Ge PET cylinder phantom (BMCY68-2030A-03), a standard reference used for normalization and daily quality control in Siemens Biograph Vision scanners. A localized hot spot was identified within the phantom, producing integral uniformity greater than 8.5% (acceptance limit ≤5%). The nonuniformity was intrinsic to the phantom material and rendered it unsuitable for quantitative use. This finding underscores the importance of independent acceptance testing of long-lived <sup>68</sup>Ge standards before clinical deployment to prevent calibration bias and ensure reliable SUV quantification.</p>\",\"PeriodicalId\":16548,\"journal\":{\"name\":\"Journal of nuclear medicine technology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2026-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of nuclear medicine technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2967/jnmt.125.271634\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nuclear medicine technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2967/jnmt.125.271634","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Nonuniformity in a Certified 68Ge PET Cylinder Phantom: Implications for Normalization Quality Assurance.
Quantitative PET imaging depends critically on the accuracy of system normalization and uniformity calibration. We report a manufacturing defect in a certified RadQual 68Ge PET cylinder phantom (BMCY68-2030A-03), a standard reference used for normalization and daily quality control in Siemens Biograph Vision scanners. A localized hot spot was identified within the phantom, producing integral uniformity greater than 8.5% (acceptance limit ≤5%). The nonuniformity was intrinsic to the phantom material and rendered it unsuitable for quantitative use. This finding underscores the importance of independent acceptance testing of long-lived 68Ge standards before clinical deployment to prevent calibration bias and ensure reliable SUV quantification.
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