A. B. Kiyaev, S. L. Safronyuk, I. M. Samokhvalov, K. S. Zakharov, A. N. Gusev, A. M. Katsev, M. A. Kiskin
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引用次数: 0
摘要
合成了铜（II）和锌（II）与1,3-二（（吡啶-2-基）-1,2,4-三唑基）丙烷（L1）和1,4-二（（吡啶-2-基）-1,2,4-三唑基）丁烷（L2）配合物。通过元素分析、热重分析、ESI质谱分析、红外光谱分析和x射线衍射研究了配合物的组成和结构。发现配合物具有[MLX]X·nH2O （X = Cl, Br; n = 3-5）组成和单核阳离子结构。配合物[Cu(L2)Cl]Cl·2.5H2O对发光试验菌（光杆菌Sh1和费雪alivibrio fcheri F1）具有较高的抑菌活性，对快速生长的人体细胞也具有高毒性。配体L2被认为是一种很有前途的化学结构，用于开发抗菌剂，无论是有机化合物还是金属配合物。
Antibacterial and Cytotoxic Properties of Zinc and Copper(II) Coordination Compounds with Bis((pyridin-2-yl)-1,2,4-triazolyl)alkanes
Copper(II) and zinc complexes with 1,3-bis((pyridin-2-yl)-1,2,4-triazolyl)propane (L1) and 1,4-bis((pyridin-2-yl)-1,2,4-triazolyl)butane (L2) were synthesized and investigated. The composition and structure of the complexes were studied by elemental and thermogravimetric analysis, ESI mass spectrometry, IR spectroscopy, and X-ray diffraction. The complexes were found to have the composition [MLX]X·nH2O (X = Cl, Br; n = 3–5) and mononuclear cationic structure. The complex [Cu(L2)Cl]Cl·2.5H2O exhibited a high antibacterial activity against luminescent test bacteria (Photobacterium leiognathi Sh1 and Aliivibrio fischeri F1) and also proved to be highly toxic against rapidly growing human cells. The ligand L2 was identified as a promising chemical structure for the development of antibacterial agents, both organic compounds and metal complexes.
期刊介绍：
Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.
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