抗dfs70阳性与系统性红斑狼疮、Sjögren综合征和系统性硬化症疾病活动性的关联：一项横断面研究

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunobiology Pub Date : 2026-05-01 Epub Date: 2026-05-22 DOI:10.1016/j.imbio.2026.153193

Esra Dilsat Imrak , Alev Cetin Duran

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引用次数: 0

摘要

目的：抗dfs70抗体被认为是系统性自身免疫性疾病中疾病活动性较低的潜在标志物，但证据仍然相互矛盾。本研究旨在探讨三种系统性自身免疫性疾病：系统性红斑狼疮（SLE）、原发性Sjögren综合征（pSS）和系统性硬化症（SSc）中抗dfs70阳性与疾病活动性之间的关系。方法本横断面研究纳入246例患者（SLE 59例，pSS 102例，SSc 85例）。免疫印迹法检测抗dfs70阳性。采用SLEDAI-2 K （SLE）、ESSDAI （pSS）和EUSTAR活性指数（SSc）评估疾病活动性。为每个疾病队列构建多元线性回归模型，调整年龄、性别、疾病特异性自身抗体、糖皮质激素使用和间质性肺疾病（SSc）。结果SLE患者14例（23.3%）、pSS患者23例（22.5%）、SSc患者12例（14.1%）中检测到dfs70抗体阳性。在单变量分析中，抗dfs70阳性SLE患者的SLEDAI-2 K评分显著降低（中位数3比4，p = 0.001），抗dsdna阳性降低（6.7%比40.0%,p = 0.014），糖皮质激素使用频率降低（13.3%比46.6%,p = 0.02）。然而，在多变量回归模型中，抗- dfs70阳性与三种疾病中的任何一种疾病的疾病活动性均无独立相关性（SLE: β = - 1.197, p = 0.191; pSS: β = - 0.181, p = 0.394; SSc: β = - 0.578, p = 0.187）。相关分析显示，SLE患者抗dfs70滴度与SLEDAI-2 K呈显著负相关（ρ = - 0.440, q < 0.001），多因素调整后，该相关性消失，与抗dsdna阳性和糖皮质激素使用混杂。结论抗- dfs70阳性与SLE、Sjögren综合征或系统性硬化症患者疾病活动性低无独立关联。

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Association of anti-DFS70 positivity with disease activity in systemic lupus erythematosus, Sjögren's syndrome, and systemic sclerosis: a cross sectional study

Objective

Anti-DFS70 antibodies have been proposed as a potential marker of lower disease activity in systemic autoimmune diseases, but evidence remains conflicting. This study aimed to investigate the association between anti-DFS70 positivity and disease activity in three systemic autoimmune diseases: systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), and systemic sclerosis (SSc).

Methods

This cross-sectional study included 246 patients (59 SLE, 102 pSS, 85 SSc). Anti-DFS70 positivity was determined by immunoblot method. Disease activity was assessed using SLEDAI-2 K (SLE), ESSDAI (pSS), and EUSTAR activity index (SSc). Multivariate linear regression models were constructed for each disease cohort, adjusting for age, sex, disease-specific autoantibodies, glucocorticoid use, and interstitial lung disease (for SSc).

Results

Anti-DFS70 positivity was observed in 14 (23.3%) SLE, 23 (22.5%) pSS, and 12 (14.1%) SSc patients. In univariate analyses, anti-DFS70-positive SLE patients had significantly lower SLEDAI-2 K scores (median 3 vs 4, p = 0.001), lower anti-dsDNA positivity (6.7% vs 40.0%, p = 0.014), and less frequent glucocorticoid use (13.3% vs 46.6%, p = 0.02). However, in multivariate regression models, anti-DFS70 positivity was not independently associated with disease activity in any of the three diseases (SLE: β = −1.197, p = 0.191; pSS: β = −0.181, p = 0.394; SSc: β = −0.578, p = 0.187). Correlation analysis revealed a significant negative correlation between anti-DFS70 titre and SLEDAI-2 K in SLE (ρ = −0.440, q < 0.001), which was lost after multivariate adjustment, confounded by anti-dsDNA positivity and glucocorticoid use.

Conclusion

No independent association was demonstrated with Anti-DFS70 positivity and low disease activity in SLE, Sjögren's syndrome, or systemic sclerosis.

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来源期刊

Immunobiology 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

108

审稿时长

55 days

期刊介绍： Immunobiology is a peer-reviewed journal that publishes highly innovative research approaches for a wide range of immunological subjects, including • Innate Immunity, • Adaptive Immunity, • Complement Biology, • Macrophage and Dendritic Cell Biology, • Parasite Immunology, • Tumour Immunology, • Clinical Immunology, • Immunogenetics, • Immunotherapy and • Immunopathology of infectious, allergic and autoimmune disease.