[以全氟三丁胺作为人工氧载体对大鼠小肠进行离体灌注]。

F Hartmann, M Plauth, D Vieillard-Baron, D Bauder
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引用次数: 0

摘要

氟碳(FC-43)作为人工氧载体可建立离体肠灌注模型。形态学、异种药物的细胞代谢(I期和II期)以及单糖的运输在至少2小时内是稳定的。在不干扰灌注介质中红细胞代谢变化的情况下,所提出的模型允许人们专门研究灌注器官的代谢功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Isolated perfusion of the small intestine of the rat with perfluorotributylamine as an artificial oxygen carrier].

A new model of isolated intestinal perfusion could be established with fluorocarbon (FC-43) as artificial oxygen carrier. Morphology, cell metabolism of xenobiotics (phase I and II), as well as the transport of a monosaccharide, were stable for at least 2 h. Without interference with the changing metabolism of erythrocytes in the perfusion medium, the proposed model allows one to investigate exclusively the metabolic function of the perfused organ.

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