神经系统中的APC。

IF 1.4 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2026-09-01 Epub Date: 2026-05-13 DOI:10.1007/s00795-026-00463-5

Takao Senda, Nami O Yamada, Takanori Onouchi

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引用次数: 0

摘要

APC （adenomatous polyposis coli）基因，作为结直肠癌抑制基因首次被发现，在神经系统中高度表达。Apc基因/Apc蛋白与大脑发育和形态发生密切相关。在出生后的大脑中，Apc/Apc参与突触传递、轴突生长和细胞内运输。Apc/Apc在神经胶质细胞中表达，通过神经胶质细胞功能参与神经胶质细胞分化和神经回路的形成。来自疾病模型动物和家族性腺瘤性息肉病（FAP）患者的报告表明，APC可能与自闭症、认知障碍和精神分裂症的发病有关。

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APC in the nervous system.

The APC (adenomatous polyposis coli) gene, which was first discovered as a colorectal cancer suppressor gene, is highly expressed in the nervous system. The Apc gene/Apc protein is deeply involved in brain development and morphogenesis. In the postnatal brain, Apc/Apc is involved in synaptic transmission, axon growth, and intracellular transport. Apc/Apc expressed in glial cells is involved in glial cell differentiation and neural circuit formation through glial cell functions. Reports from disease model animals and familial adenomatous polyposis (FAP) patients suggest that APC may be involved in the onset of autism, cognitive impairment, and schizophrenia.

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.