槲皮素壳聚糖包被油质体和杨梅介导氧化锌纳米颗粒在抗病毒、抗炎和保肝治疗中的生物物理特性

IF 5 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2026-04-29 DOI:10.1007/s10924-026-03838-y

Mofida E. M. Makhlof, Mariam Zewail, Sahar E. Abo-Neima, Mohammad Y. Alfaifi, Ali A. Shati, Fatma Alzahraa Mokhtar

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引用次数: 0

摘要

本研究介绍了一种新的基于晶圆的纳米平台，将槲皮素（QER）负载，壳聚糖包被的油质体（F3）与绿色合成的杨梅多枝菌介导的氧化锌纳米粒子（PZnONPs, 22.95-29.51 nm）整合到羧甲基纤维素钠（NaCMC）基质中，以增强抗病毒，抗炎和肝脏保护作用。综合表征证实了纳米级的均匀性，高QER包封率（96.7%），正的ζ-电位（+19.7 mV），以及F3油质体的双相缓释（长达120 h），进一步延长到144 h，最大限度地减少了晶圆中的爆裂。与游离QER相比，双负载的F3/PZnONPs晶圆具有更好的肝保护作用（IC50 = 23.25 μ g/mL），通过纳米包封协同作用提高了HAV抗病毒活性，尽管急性效价较低（与游离QER相比IC50 = 4.67 μ g/mL），但仍能持续抑制COX-2，突出了延长多靶点递送的新颖性。这些发现强调了该平台的临床翻译潜力，有待体内验证。此图像的替代文本可能是使用AI生成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biophysical Characterization of Wafers Co-loading Quercetin Loaded Chitosan-Coated Oleosomes and Polycladia Myrica-Mediated Zinc Oxide Nanoparticles for Antiviral, Anti-inflammatory and Hepatoprotective Therapy

查看原文本刊更多论文

This study introduces a novel wafer-based nanoplatform integrating quercetin (QER)-loaded, chitosan-coated oleosomes (F3) with green-synthesized Polycladia myrica-mediated zinc oxide nanoparticles (PZnONPs, 22.95–29.51 nm) into sodium carboxymethyl cellulose (NaCMC) matrices for enhanced antiviral, anti-inflammatory, and hepatoprotective effects. Comprehensive characterization confirmed nanoscale uniformity, high QER encapsulation (96.7%), positive ζ-potential (+19.7 mV), and biphasic sustained release from F3 oleosomes (up to 120 h), further extended to 144 h in wafers with minimized burst. The dual-loaded F3/PZnONPs wafers exhibited superior hepatoprotection (IC50 = 23.25 µg/mL) over free QER, improved HAV antiviral activity via nanoencapsulation synergy, and sustained COX-2 inhibition despite lower acute potency (vs. free QER IC50 = 4.67 µg/mL), highlighting the novelty of prolonged multi-target delivery. These findings underscore the platform’s clinical translation potential, pending in vivo validation.

Graphical Abstract

The alternative text for this image may have been generated using AI.

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.