Yule Hu, Yueying Wang, Meizhen Huang, Daniel D Hodgkiss, Tom E Nightingale, Mengqi Li, Kun Li, Yan Li, Angela Y M Leung
{"title":"成人脊髓损伤患者抑郁与认知功能的关系：系统回顾和荟萃分析。","authors":"Yule Hu, Yueying Wang, Meizhen Huang, Daniel D Hodgkiss, Tom E Nightingale, Mengqi Li, Kun Li, Yan Li, Angela Y M Leung","doi":"10.1038/s41393-026-01205-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Study design: </strong>Systematic review and meta-analysis.</p><p><strong>Objectives: </strong>Despite a growing prevalence of cognitive impairment and depression after spinal cord injury (SCI), evidence of associations between specific cognitive domains and processes with depressive symptoms remains uncertain. This systematic review with meta-analysis aimed to evaluate the relationship between cognitive functions and depressive symptoms in adults with SCI.</p><p><strong>Methods: </strong>This review was pre-registered with PROSPERO (CRD42024523479). Seven databases were searched from inception to March 2025. Eligible studies assessed depression and cognitive function in adults with SCI and were published in English. Cognitive functions included self-reported subjective cognitive failures and objective cognitive functions assessed by neuropsychological tests. Study quality was assessed via the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Ten studies (three cohort, seven cross-sectional; N = 1683 participants) were included, with seven studies eligible for meta-analysis. The pooled results revealed that elevated depressive symptoms are significantly associated with global cognitive impairment, whereas there were no associations with subjective cognitive decline or deficits in specific domains (i.e., executive function, attention, and learning and memory).</p><p><strong>Conclusions: </strong>Adults with SCI who have impaired global cognitive function exhibit higher levels of depressive symptoms. Interventions targeting either depression or cognitive function may yield concomitant benefits on both outcomes, thereby enhancing health-related quality of life of the SCI population. More prospective studies are needed to investigate the relationship between depression severity and specific cognitive domains and to elucidate their potential causal mechanisms.</p>","PeriodicalId":21976,"journal":{"name":"Spinal cord","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The relationship between depression and cognitive function among adults with spinal cord injury: a systematic review and meta-analysis.\",\"authors\":\"Yule Hu, Yueying Wang, Meizhen Huang, Daniel D Hodgkiss, Tom E Nightingale, Mengqi Li, Kun Li, Yan Li, Angela Y M Leung\",\"doi\":\"10.1038/s41393-026-01205-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Study design: </strong>Systematic review and meta-analysis.</p><p><strong>Objectives: </strong>Despite a growing prevalence of cognitive impairment and depression after spinal cord injury (SCI), evidence of associations between specific cognitive domains and processes with depressive symptoms remains uncertain. This systematic review with meta-analysis aimed to evaluate the relationship between cognitive functions and depressive symptoms in adults with SCI.</p><p><strong>Methods: </strong>This review was pre-registered with PROSPERO (CRD42024523479). Seven databases were searched from inception to March 2025. Eligible studies assessed depression and cognitive function in adults with SCI and were published in English. Cognitive functions included self-reported subjective cognitive failures and objective cognitive functions assessed by neuropsychological tests. Study quality was assessed via the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Ten studies (three cohort, seven cross-sectional; N = 1683 participants) were included, with seven studies eligible for meta-analysis. The pooled results revealed that elevated depressive symptoms are significantly associated with global cognitive impairment, whereas there were no associations with subjective cognitive decline or deficits in specific domains (i.e., executive function, attention, and learning and memory).</p><p><strong>Conclusions: </strong>Adults with SCI who have impaired global cognitive function exhibit higher levels of depressive symptoms. Interventions targeting either depression or cognitive function may yield concomitant benefits on both outcomes, thereby enhancing health-related quality of life of the SCI population. More prospective studies are needed to investigate the relationship between depression severity and specific cognitive domains and to elucidate their potential causal mechanisms.</p>\",\"PeriodicalId\":21976,\"journal\":{\"name\":\"Spinal cord\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2026-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Spinal cord\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41393-026-01205-1\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Spinal cord","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41393-026-01205-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
The relationship between depression and cognitive function among adults with spinal cord injury: a systematic review and meta-analysis.
Study design: Systematic review and meta-analysis.
Objectives: Despite a growing prevalence of cognitive impairment and depression after spinal cord injury (SCI), evidence of associations between specific cognitive domains and processes with depressive symptoms remains uncertain. This systematic review with meta-analysis aimed to evaluate the relationship between cognitive functions and depressive symptoms in adults with SCI.
Methods: This review was pre-registered with PROSPERO (CRD42024523479). Seven databases were searched from inception to March 2025. Eligible studies assessed depression and cognitive function in adults with SCI and were published in English. Cognitive functions included self-reported subjective cognitive failures and objective cognitive functions assessed by neuropsychological tests. Study quality was assessed via the Newcastle-Ottawa Scale.
Results: Ten studies (three cohort, seven cross-sectional; N = 1683 participants) were included, with seven studies eligible for meta-analysis. The pooled results revealed that elevated depressive symptoms are significantly associated with global cognitive impairment, whereas there were no associations with subjective cognitive decline or deficits in specific domains (i.e., executive function, attention, and learning and memory).
Conclusions: Adults with SCI who have impaired global cognitive function exhibit higher levels of depressive symptoms. Interventions targeting either depression or cognitive function may yield concomitant benefits on both outcomes, thereby enhancing health-related quality of life of the SCI population. More prospective studies are needed to investigate the relationship between depression severity and specific cognitive domains and to elucidate their potential causal mechanisms.
期刊介绍：
Spinal Cord is a specialised, international journal that has been publishing spinal cord related manuscripts since 1963. It appears monthly, online and in print, and accepts contributions on spinal cord anatomy, physiology, management of injury and disease, and the quality of life and life circumstances of people with a spinal cord injury. Spinal Cord is multi-disciplinary and publishes contributions across the entire spectrum of research ranging from basic science to applied clinical research. It focuses on high quality original research, systematic reviews and narrative reviews.
Spinal Cord''s sister journal Spinal Cord Series and Cases: Clinical Management in Spinal Cord Disorders publishes high quality case reports, small case series, pilot and retrospective studies perspectives, Pulse survey articles, Point-couterpoint articles, correspondences and book reviews. It specialises in material that addresses all aspects of life for persons with spinal cord injuries or disorders. For more information, please see the aims and scope of Spinal Cord Series and Cases.
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