伸展运动或步行对纤维肌痛患者的生活质量没有临床意义的改善：一项非随机对照临床试验

Q4 Health Professions

Fisioterapia Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI:10.1016/j.ft.2026.01.001

A. Pontes-Silva, M.A. Avila

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引用次数: 0

摘要

考虑到步行是纤维肌痛试验中研究最多的运动，并且在之前的试验中没有作为阳性对照进行测试，那么问题来了：伸展运动是否能在纤维肌痛患者中提供与步行相似的临床益处？目的探讨伸展运动对纤维肌痛患者中强度步行阳性对照组生活质量的影响（单一主要结局）。方法非随机对照临床试验。我们使用FIQ-R来评估研究的单一主要结局：生活质量。阳性对照组干预：中强度步行40分钟，2次/周，持续12周+ 12周无运动随访。拉伸组干预：中等强度拉伸，2次/周，持续12周+ 10周无运动随访。我们使用混合线性模型、时间×组相互作用、Bonferroni post hoc和Cohen’s d来比较生活质量，以检验显著差异的效应大小（α = 0.05）。结果225例纤维肌痛志愿者分为两组：步行组（n = 15，年龄45±9.93）和拉伸组（n = 210，年龄47.81±1.57）。我们的研究没有发现不良反应，也没有坚持干预。组间比较显示，在基线、第6周、第12周和随访的所有时间点，纤维肌痛患者的生活质量无显著差异（p > 0.05）。在组内比较中，只有步行组在基线- 6周（17.44 [95% CI: 4.30, 30.57]）、基线- 12周（17.19 [95% CI: 1.16, 33.21]）和基线-随访（16.84 [95% CI: 1.78, 31.90]）的所有时间点与基线有显著差异（p≤0.05,d≥0.5）。然而，这些差异没有达到最小临床重要差异阈值。结论伸展运动或步行对纤维肌痛患者的生活质量没有临床意义的改善。

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Stretching exercises or walking did not produce clinically meaningful improvements in the quality of life of patients with fibromyalgia: A non-randomized controlled clinical trial

Overview

Considering that walking is the most studied exercise in fibromyalgia trials, and it has not been tested as a positive-control in previous trials, the question arises: does stretching exercises provide similar clinical benefits to walking as a positive-control in fibromyalgia patients?

Objective

To test the effects of stretching exercises on quality of life (single primary outcome) against a positive-control group of moderate-intensity walking in fibromyalgia patients.

Methods

Non-randomized controlled clinical trial. We used the FIQ-R to evaluate the single primary outcome of the study: quality of life. Intervention in positive-control group: 40 min of moderate-intensity walking, 2×/week, 12 weeks duration + 12 weeks follow-up without exercise. Intervention in the stretching group: moderate intensity stretching, 2×/week, 12 weeks duration + 10 weeks follow-up without exercise. We compared the quality of life using mixed linear models, time × group interaction, Bonferroni post hoc, and Cohen's d to test the effect size of significant differences (α = 0.05).

Results

The total sample consisted of 225 volunteer fibromyalgia patients who were divided into two groups: a walking group (n = 15, age 45 ± 9.93) and a stretching group (n = 210, age 47.81 ± 1.57). Our study found no adverse effects and no adherence to the intervention. Between-group comparisons revealed non-significant differences (p > .05) in quality of life for fibromyalgia patients at all time points: baseline, 6th week, 12th week, and follow-up. In the within-group comparisons, only the walking group showed significant differences (p ≤ .05, d ≥ .5) from baseline at all time points: baseline–6th week (17.44 [95% CI: 4.30, 30.57]), baseline–12th week (17.19 [95% CI: 1.16, 33.21]), and baseline–follow-up (16.84 [95% CI: 1.78, 31.90]). However, these differences did not reach the minimal clinically important difference threshold.

Conclusion

Stretching exercises or walking did not produce clinically meaningful improvements in the quality of life of patients with fibromyalgia.

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来源期刊

Fisioterapia Health Professions-Physical Therapy, Sports Therapy and Rehabilitation

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Publicación Oficial de la Sociedad Española de Fisioterapeutas. Sus páginas ofrecen desde artículos originales hasta revisiones, pasando por el estudio de casos o los actos más importantes relacionados con la especialidad.