异恶唑策略合成姜黄素和去甲氧基姜黄素

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2026-04-03 Epub Date: 2026-03-31 DOI:10.1080/00397911.2026.2649255

Mirai Kato (Investigation Writing – original draft) , Kyosuke Sugihara (Investigation) , Aki Tanaka (Investigation Writing – review & editing) , Rina Tanaka (Investigation) , Hitoshi Abe (Conceptualization Project administration Supervision Writing – review & editing)

引用次数: 0

摘要

采用异恶唑掩蔽策略合成了姜黄素和去甲氧基姜黄素。一个3,5-二取代异恶唑是由一个氧化腈和一个炔[3 + 2]环加成得到的，经过温和的还原性N-O裂解，以良好的收率显示出β-二酮核心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An isoxazole strategy for the synthesis of curcumin and demethoxycurcumin

Curcumin and demethoxycurcumin were synthesized via an isoxazole-masking strategy. A 3,5-disubstituted isoxazole, obtained by [3 + 2] cycloaddition of a nitrile oxide and an alkyne, underwent mild reductive N-O cleavage to reveal the β-diketone core in good yield.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.