{"title":"肠-肝轴控制着药物传递载体的命运","authors":"Sadra Bakhshandeh","doi":"10.1038/s44222-026-00436-4","DOIUrl":null,"url":null,"abstract":"An article in Science reports a previously unrecognized gut microbiota-driven endocrine circuit that maintains Kupffer cell activation, thereby dictating the systemic efficiency of therapies delivered by nanocarriers.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 4","pages":"300-300"},"PeriodicalIF":37.6000,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A gut–liver axis governs the fate of drug delivery vectors\",\"authors\":\"Sadra Bakhshandeh\",\"doi\":\"10.1038/s44222-026-00436-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An article in Science reports a previously unrecognized gut microbiota-driven endocrine circuit that maintains Kupffer cell activation, thereby dictating the systemic efficiency of therapies delivered by nanocarriers.\",\"PeriodicalId\":74248,\"journal\":{\"name\":\"Nature reviews bioengineering\",\"volume\":\"4 4\",\"pages\":\"300-300\"},\"PeriodicalIF\":37.6000,\"publicationDate\":\"2026-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44222-026-00436-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-026-00436-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A gut–liver axis governs the fate of drug delivery vectors
An article in Science reports a previously unrecognized gut microbiota-driven endocrine circuit that maintains Kupffer cell activation, thereby dictating the systemic efficiency of therapies delivered by nanocarriers.
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