T Miura, H Kessoku, T Kobayashi, M Nagaoka, H Kojima
{"title":"头颈癌手术前后预后营养指数的动态变化。","authors":"T Miura, H Kessoku, T Kobayashi, M Nagaoka, H Kojima","doi":"10.1016/j.anorl.2026.03.002","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the relationship between changes in the prognostic nutritional index (PNI), which is an indicator of nutritional status, and outcomes in patients with head and neck cancer who underwent surgery at our hospital.</p><p><strong>Material and methods: </strong>We retrospectively reviewed the medical records of 148 patients (128 men and 20 women) who underwent surgery from 2015 to 2022. The median age was 68.5 (range: 40-88) years. Overall survival (OS) was calculated using the Kaplan-Meier method. The PNI was calculated preoperatively and postoperatively. Based on changes in pre- and post-treatment, patients were categorized as having high PNI both before and after surgery (high-to-high [HTH]), low PNI before and high PNI after surgery (low-to-high [LTH]), high PNI before and low PNI after surgery (high-to-low [HTL]), and low PNI both preoperatively and postoperatively (low-to-low [LTL]).</p><p><strong>Objectives: </strong>The effects of pre- and post-treatment changes in the PNI on patient outcomes were determined using the Cox proportional hazards model.</p><p><strong>Results: </strong>The median PNI was 49 and 48 before and after surgery, respectively. In the multivariate analysis, preoperative PNI was an independent poor prognostic factor for disease-free survival (DFS) and OS (P=0.037 and P=0.039). The postoperative PNI was an independent poor prognostic factor for DFS and OS (P<0.01). In the univariate analysis, the HTL and LTL groups showed poorer patient outcomes when the HTH group was used as a reference.</p><p><strong>Conclusion: </strong>Changes in PNI could be a useful indicator of postoperative outcomes in patients with head and neck cancer.</p>","PeriodicalId":48834,"journal":{"name":"European Annals of Otorhinolaryngology-Head and Neck Diseases","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dynamics of prognostic nutritional index before and after surgery in head and neck cancer.\",\"authors\":\"T Miura, H Kessoku, T Kobayashi, M Nagaoka, H Kojima\",\"doi\":\"10.1016/j.anorl.2026.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>To evaluate the relationship between changes in the prognostic nutritional index (PNI), which is an indicator of nutritional status, and outcomes in patients with head and neck cancer who underwent surgery at our hospital.</p><p><strong>Material and methods: </strong>We retrospectively reviewed the medical records of 148 patients (128 men and 20 women) who underwent surgery from 2015 to 2022. The median age was 68.5 (range: 40-88) years. Overall survival (OS) was calculated using the Kaplan-Meier method. The PNI was calculated preoperatively and postoperatively. Based on changes in pre- and post-treatment, patients were categorized as having high PNI both before and after surgery (high-to-high [HTH]), low PNI before and high PNI after surgery (low-to-high [LTH]), high PNI before and low PNI after surgery (high-to-low [HTL]), and low PNI both preoperatively and postoperatively (low-to-low [LTL]).</p><p><strong>Objectives: </strong>The effects of pre- and post-treatment changes in the PNI on patient outcomes were determined using the Cox proportional hazards model.</p><p><strong>Results: </strong>The median PNI was 49 and 48 before and after surgery, respectively. In the multivariate analysis, preoperative PNI was an independent poor prognostic factor for disease-free survival (DFS) and OS (P=0.037 and P=0.039). The postoperative PNI was an independent poor prognostic factor for DFS and OS (P<0.01). In the univariate analysis, the HTL and LTL groups showed poorer patient outcomes when the HTH group was used as a reference.</p><p><strong>Conclusion: </strong>Changes in PNI could be a useful indicator of postoperative outcomes in patients with head and neck cancer.</p>\",\"PeriodicalId\":48834,\"journal\":{\"name\":\"European Annals of Otorhinolaryngology-Head and Neck Diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2026-04-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Annals of Otorhinolaryngology-Head and Neck Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.anorl.2026.03.002\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Annals of Otorhinolaryngology-Head and Neck Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.anorl.2026.03.002","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Dynamics of prognostic nutritional index before and after surgery in head and neck cancer.
Aims: To evaluate the relationship between changes in the prognostic nutritional index (PNI), which is an indicator of nutritional status, and outcomes in patients with head and neck cancer who underwent surgery at our hospital.
Material and methods: We retrospectively reviewed the medical records of 148 patients (128 men and 20 women) who underwent surgery from 2015 to 2022. The median age was 68.5 (range: 40-88) years. Overall survival (OS) was calculated using the Kaplan-Meier method. The PNI was calculated preoperatively and postoperatively. Based on changes in pre- and post-treatment, patients were categorized as having high PNI both before and after surgery (high-to-high [HTH]), low PNI before and high PNI after surgery (low-to-high [LTH]), high PNI before and low PNI after surgery (high-to-low [HTL]), and low PNI both preoperatively and postoperatively (low-to-low [LTL]).
Objectives: The effects of pre- and post-treatment changes in the PNI on patient outcomes were determined using the Cox proportional hazards model.
Results: The median PNI was 49 and 48 before and after surgery, respectively. In the multivariate analysis, preoperative PNI was an independent poor prognostic factor for disease-free survival (DFS) and OS (P=0.037 and P=0.039). The postoperative PNI was an independent poor prognostic factor for DFS and OS (P<0.01). In the univariate analysis, the HTL and LTL groups showed poorer patient outcomes when the HTH group was used as a reference.
Conclusion: Changes in PNI could be a useful indicator of postoperative outcomes in patients with head and neck cancer.
期刊介绍：
European Annals of Oto-rhino-laryngology, Head and Neck diseases heir of one of the oldest otorhinolaryngology journals in Europe is the official organ of the French Society of Otorhinolaryngology (SFORL) and the the International Francophone Society of Otorhinolaryngology (SIFORL). Today six annual issues provide original peer reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches and review articles giving most up-to-date insights in all areas of otology, laryngology rhinology, head and neck surgery. The European Annals also publish the SFORL guidelines and recommendations.The journal is a unique two-armed publication: the European Annals (ANORL) is an English language well referenced online journal (e-only) whereas the Annales Françaises d’ORL (AFORL), mail-order paper and online edition in French language are aimed at the French-speaking community. French language teams must submit their articles in French to the AFORL site.
Federating journal in its field, the European Annals has an Editorial board of experts with international reputation that allow to make an important contribution to communication on new research data and clinical practice by publishing high-quality articles.
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