[A Case Report of Successful Control of Refractory Tumor Fever in Lung Adenocarcinoma with Interleukin-6 Antibody Tocilizumab].

Fever is a common symptom of lung cancer, but most are induced by infection. This is the first report of a patient with lung adenocarcinoma who developed a fever of unknown origin for more than 1 month after repeat biopsy on the progression of first-line treatment in China. Comprehensive blood tests, the well-known pathogens were fully examined, and imaging studies failed to support infectious fever, connective tissue disease-related fever, drug fever, or other etiologies, leading to the diagnosis of tumor fever. While the fever remained refractory to Ibuprofen, it was successfully controlled 12 h after a single intravenous administration of Tocilizumab, with the patient maintaining a normal body temperature for 45 days, from August 21 to October 4, 2025. This case report primarily provides the practice for exploring the tumor fever.
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