全胰腺切除术和胰岛自体移植术后健康相关生活质量的系统评价和荟萃分析

IF 2.7 2区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Pancreatology Pub Date : 2026-05-01 Epub Date: 2026-03-19 DOI:10.1016/j.pan.2026.03.015

Kurt Carabott , Matta Kuzman , Samuel Tingle , Vivek Peddakota , Maisam Abu-El-Haija , Melena Bellin , Steven White , Sanjay Pandanaboyana

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引用次数: 0

摘要

目的：系统回顾有关慢性胰腺炎（CP）全胰切除术后胰岛移植术后生活质量（QOL）的文献。背景：全胰切除术和胰岛自体移植（TPIAT）旨在减轻CP患者的疼痛，同时保持β细胞功能。方法：根据PRISMA框架对Medline、PubMed、EMBASE进行系统检索，找出报道TPIAT治疗CP后生活质量的研究。采用随机效应荟萃分析，汇总物理成分总结（PCS）和心理成分总结（MCS）生活质量评分变化的结果。结果：2011年至2025年间进行了29项研究，共纳入4075名患者，其中24.8%为儿科患者。19项研究使用RAND SF36 QOL仪器，这是使用最多的仪器。生活质量调查在tpiat后1个月至10年以上进行。应答率从14%到100%不等。TPIAT后1年PCS评分显著提高(汇总估计10.36,95% CI 7.33至13.4,p =结论：TPIAT在生活质量的身体和精神成分方面提供了短期和长期的改善。然而，开发TPIAT特定的生活质量仪器是必要的，以捕获决定生活质量的TPIAT特定结果。

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Systematic review and meta-analysis of health-related quality of life outcomes after total pancreatectomy and islet auto-transplantation

Objective

To systematically review the literature on quality of life (QOL) after islet transplantation following total pancreatectomy in chronic pancreatitis (CP).

Background

Total pancreatectomy and islet auto-transplantation (TPIAT) aims to relieve pain while preserving β-cell function in CP patients.

Methods

A systematic search of Medline, PubMed, EMBASE was performed according to PRISMA framework to identify studies reporting on QOL after TPIAT for CP. Random effects meta-analyses were performed to pool results on change in physical component summary (PCS) and mental component summary (MCS) QOL scores.

Results

Twenty-nine studies performed between 2011 and 2025 with a total of 4075 patients were included of which 24.8% were paediatric patients. 19 studies used the RAND SF36 QOL instrument, the most used instrument. The QOL surveys were performed from 1 month to more than 10 years post-TPIAT. Response rates varied from 14% to 100%. PCS scores were significantly higher at 1-year post-TPIAT (pooled estimate 10.36, 95% CI 7.33 to 13.4, p = <0.001) and at longest follow up (pooled estimate 16.07, 95% CI 5.80 to 26.34, p = 0.002). MCS scores were also significantly higher at 1-year post-TPIAT (pooled estimate 5.54, 95% CI 3.30 to 7.78, p = <0.001) and at longest follow up (pooled estimate 13.26, 95% CI 3.67 to 22.85, p = 0.007). Improvements in QOL appear to persist beyond 10 years.

Conclusion

TPIAT offers both short-term and long-term improvements in physical and mental components of QOL. However, development of TPIAT specific QOL instrument is warranted to capture TPIAT specific outcomes which determine QOL.

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来源期刊

Pancreatology 医学-胃肠肝病学

CiteScore

7.20

自引率

5.60%

发文量

194

审稿时长

44 days

期刊介绍： Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.