{"title":"幽门螺杆菌感染状况及癌前病变风险的变化：中国人群的前瞻性队列研究。","authors":"Xufei Xing, Renjia Zhao, Zixuan Cui, Qiaoyi Xu, Ziyu Yuan, Kelin Xu, Tiejun Zhang, Zhenqiu Liu, Yanfeng Jiang, Ming Lu, Weimin Ye, Chen Suo, Xingdong Chen","doi":"10.1111/hel.70114","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>To evaluate the associations of both baseline serological profiles and serological transitions of <i>Helicobacter pylori</i> infection patterns with the risk of precancerous gastric lesions (PGLs).</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>We analyzed data from 6208 participants in the FuSion cohort who underwent gastroscopy examination, with available <i>H. pylori</i> antibody and pepsinogen measurements at both baseline and follow-up. <i>H. pylori</i> status defined by IgG antibodies (Ab) and pepsinogens (PG), classified participants into four ABC groups. Multivariable logistic regression evaluated associations with PGLs across baseline and transition statuses. Trend tests were performed across the ABC groups and infection transition categories.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A significant increasing trend in the PGLs prevalence and severity was observed across the ABC groups (<i>p</i> for trend < 0.05). Analysis of infection transitions revealed graded risk increases for PGLs from consistently negative to remained positive groups. Interestingly, even participants who seroreverted remained at significantly elevated risks of atrophic gastritis (adjusted odds ratio [aOR] = 2.01, 95% CI: 1.67–2.43) and intestinal metaplasia (aOR = 1.72, 95% CI: 1.14–2.51) compared to the persistently negative participants. The sensitivity analyses excluding baseline PG-positive subjects yielded similar results.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Long-term exposure to <i>H. pylori</i> is associated with an increased risk of PGLs, and this risk may remain elevated even after seroreversion.</p>\n </section>\n </div>","PeriodicalId":13223,"journal":{"name":"Helicobacter","volume":"31 2","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Changes of Helicobacter pylori Infection Status and Risk of Precancerous Lesions: A Prospective Cohort Study in Chinese Population\",\"authors\":\"Xufei Xing, Renjia Zhao, Zixuan Cui, Qiaoyi Xu, Ziyu Yuan, Kelin Xu, Tiejun Zhang, Zhenqiu Liu, Yanfeng Jiang, Ming Lu, Weimin Ye, Chen Suo, Xingdong Chen\",\"doi\":\"10.1111/hel.70114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To evaluate the associations of both baseline serological profiles and serological transitions of <i>Helicobacter pylori</i> infection patterns with the risk of precancerous gastric lesions (PGLs).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Design</h3>\\n \\n <p>We analyzed data from 6208 participants in the FuSion cohort who underwent gastroscopy examination, with available <i>H. pylori</i> antibody and pepsinogen measurements at both baseline and follow-up. <i>H. pylori</i> status defined by IgG antibodies (Ab) and pepsinogens (PG), classified participants into four ABC groups. Multivariable logistic regression evaluated associations with PGLs across baseline and transition statuses. Trend tests were performed across the ABC groups and infection transition categories.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>A significant increasing trend in the PGLs prevalence and severity was observed across the ABC groups (<i>p</i> for trend < 0.05). Analysis of infection transitions revealed graded risk increases for PGLs from consistently negative to remained positive groups. Interestingly, even participants who seroreverted remained at significantly elevated risks of atrophic gastritis (adjusted odds ratio [aOR] = 2.01, 95% CI: 1.67–2.43) and intestinal metaplasia (aOR = 1.72, 95% CI: 1.14–2.51) compared to the persistently negative participants. The sensitivity analyses excluding baseline PG-positive subjects yielded similar results.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Long-term exposure to <i>H. pylori</i> is associated with an increased risk of PGLs, and this risk may remain elevated even after seroreversion.</p>\\n </section>\\n </div>\",\"PeriodicalId\":13223,\"journal\":{\"name\":\"Helicobacter\",\"volume\":\"31 2\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2026-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Helicobacter\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/hel.70114\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helicobacter","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/hel.70114","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Changes of Helicobacter pylori Infection Status and Risk of Precancerous Lesions: A Prospective Cohort Study in Chinese Population
Objective
To evaluate the associations of both baseline serological profiles and serological transitions of Helicobacter pylori infection patterns with the risk of precancerous gastric lesions (PGLs).
Design
We analyzed data from 6208 participants in the FuSion cohort who underwent gastroscopy examination, with available H. pylori antibody and pepsinogen measurements at both baseline and follow-up. H. pylori status defined by IgG antibodies (Ab) and pepsinogens (PG), classified participants into four ABC groups. Multivariable logistic regression evaluated associations with PGLs across baseline and transition statuses. Trend tests were performed across the ABC groups and infection transition categories.
Results
A significant increasing trend in the PGLs prevalence and severity was observed across the ABC groups (p for trend < 0.05). Analysis of infection transitions revealed graded risk increases for PGLs from consistently negative to remained positive groups. Interestingly, even participants who seroreverted remained at significantly elevated risks of atrophic gastritis (adjusted odds ratio [aOR] = 2.01, 95% CI: 1.67–2.43) and intestinal metaplasia (aOR = 1.72, 95% CI: 1.14–2.51) compared to the persistently negative participants. The sensitivity analyses excluding baseline PG-positive subjects yielded similar results.
Conclusion
Long-term exposure to H. pylori is associated with an increased risk of PGLs, and this risk may remain elevated even after seroreversion.
期刊介绍：
Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.
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