奎宁酸在全合成中的作用。

IF 12.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2026-05-27 Epub Date: 2026-03-03 DOI:10.1039/d5np00087d

Manuel J. Verganista , Iago C. Vogel , Nuno R. Candeias

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引用次数: 0

摘要

时间跨度：1980年至2025年。奎宁酸成为不对称合成的一种通用的、可接近的手性构件，提供了一种功能化的、立体化学丰富的支架，使许多天然产物和生物活性化合物的产生成为可能。本文综述了从20世纪80年代到2025年的合成策略，强调了奎宁酸在有机合成中的持续重要性。讨论了其在合成碳环框架、维生素D类似物、碳糖、环醇、氨基环醇、内酯、生物碱和大环片段中的作用。这篇综述总结了四十年来的进展和新兴趋势，这些进展和趋势加强了奎宁酸作为复杂分子合成的关键手性构建块的地位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Quinic acid as a chiron in total synthesis†

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Quinic acid as a chiron in total synthesis†

Covering: 1980 up to 2025.

Quinic acid became a versatile, accessible chiral building block for asymmetric synthesis, offering a functionalized, stereochemically rich scaffold that enables the creation of many natural products and bioactive compounds. This review covers synthetic strategies from the 1980s to 2025, highlighting quinic acid's ongoing importance in organic synthesis. It discusses its role in synthesizing carbocyclic frameworks, vitamin D analogues, carbasugars, cyclitols, aminocyclitols, lactones, alkaloids, and macrocyclic fragments. The review summarizes four decades of progress and emerging trends that reinforce quinic acid's status as a key chiral building block for complex molecule synthesis.

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.