{"title":"结核病治疗期间的免疫重建炎症综合征。","authors":"Melis Deniz, Özge Kaba, Ercan Ayaz, Ayşe Pervanlar Kakışım, Burak Kocaağa, Nurhayat Yakut, Canan Caymaz","doi":"10.4269/ajtmh.25-0641","DOIUrl":null,"url":null,"abstract":"<p><p>Pediatric patients with tuberculosis who are not infected with HIV may still be at risk of developing tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) during treatment. A case of TB-IRIS in an immunocompetent child with pulmonary tuberculosis is reported. On the 25th day of standard antituberculosis therapy, the patient experienced continuous fever and clinical deterioration, and new lesions were detected on follow-up radiographic imaging. Upon initiation of corticosteroid therapy, the patient showed marked clinical improvement and resolution of fever. This case highlights the importance of recognizing TB-IRIS in immunocompetent pediatric patients. After alternative causes are excluded, TB-IRIS should be suspected in children with tuberculosis who develop new or worsening symptoms accompanied by newly emerging radiological findings.</p>","PeriodicalId":7752,"journal":{"name":"American Journal of Tropical Medicine and Hygiene","volume":" ","pages":"629-632"},"PeriodicalIF":1.6000,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045567/pdf/","citationCount":"0","resultStr":"{\"title\":\"Tuberculosis-Immune Reconstitution Inflammatory Syndrome During Tuberculosis Treatment.\",\"authors\":\"Melis Deniz, Özge Kaba, Ercan Ayaz, Ayşe Pervanlar Kakışım, Burak Kocaağa, Nurhayat Yakut, Canan Caymaz\",\"doi\":\"10.4269/ajtmh.25-0641\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pediatric patients with tuberculosis who are not infected with HIV may still be at risk of developing tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) during treatment. A case of TB-IRIS in an immunocompetent child with pulmonary tuberculosis is reported. On the 25th day of standard antituberculosis therapy, the patient experienced continuous fever and clinical deterioration, and new lesions were detected on follow-up radiographic imaging. Upon initiation of corticosteroid therapy, the patient showed marked clinical improvement and resolution of fever. This case highlights the importance of recognizing TB-IRIS in immunocompetent pediatric patients. After alternative causes are excluded, TB-IRIS should be suspected in children with tuberculosis who develop new or worsening symptoms accompanied by newly emerging radiological findings.</p>\",\"PeriodicalId\":7752,\"journal\":{\"name\":\"American Journal of Tropical Medicine and Hygiene\",\"volume\":\" \",\"pages\":\"629-632\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2026-02-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13045567/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Tropical Medicine and Hygiene\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4269/ajtmh.25-0641\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2026/4/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q3\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Tropical Medicine and Hygiene","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4269/ajtmh.25-0641","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/4/1 0:00:00","PubModel":"Print","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Tuberculosis-Immune Reconstitution Inflammatory Syndrome During Tuberculosis Treatment.
Pediatric patients with tuberculosis who are not infected with HIV may still be at risk of developing tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) during treatment. A case of TB-IRIS in an immunocompetent child with pulmonary tuberculosis is reported. On the 25th day of standard antituberculosis therapy, the patient experienced continuous fever and clinical deterioration, and new lesions were detected on follow-up radiographic imaging. Upon initiation of corticosteroid therapy, the patient showed marked clinical improvement and resolution of fever. This case highlights the importance of recognizing TB-IRIS in immunocompetent pediatric patients. After alternative causes are excluded, TB-IRIS should be suspected in children with tuberculosis who develop new or worsening symptoms accompanied by newly emerging radiological findings.
期刊介绍：
The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine.
The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development.
The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal.
Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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