中性粒细胞胞外陷阱在动脉粥样硬化中的作用。

IF 3 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Current Research in Translational Medicine Pub Date : 2026-01-01 Epub Date: 2026-02-18 DOI:10.1016/j.retram.2026.103570

Haoran Zhang , Yulun Wu , Qingqing Xiao , Shuangshuang Gong , Shixian Shao , Minghui Ma , Mo Wang , Xiaowen Liu

{"title":"中性粒细胞胞外陷阱在动脉粥样硬化中的作用。","authors":"Haoran Zhang , Yulun Wu , Qingqing Xiao , Shuangshuang Gong , Shixian Shao , Minghui Ma , Mo Wang , Xiaowen Liu","doi":"10.1016/j.retram.2026.103570","DOIUrl":null,"url":null,"abstract":"<div><div>Neutrophils extracellular traps (NETs), released by neutrophils, play a core role in the occurrence and development of atherosclerosis (AS) lesions, which components damage endothelium, destabilize plaques by inducing vascular smooth muscle cell death, and exacerbate inflammation and thrombosis via interactions with phagocytes, platelets, and T cells. By blocking the production pathway of NETs and degrading the components of NETs are all feasible methods that could be explored to reduce AS. Here, we reviewed the NETs’ role in AS and their therapeutic potential, offering clinical translation insights.</div></div>","PeriodicalId":54260,"journal":{"name":"Current Research in Translational Medicine","volume":"74 1","pages":"Article 103570"},"PeriodicalIF":3.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of neutrophil extracellular traps in atherosclerosis\",\"authors\":\"Haoran Zhang , Yulun Wu , Qingqing Xiao , Shuangshuang Gong , Shixian Shao , Minghui Ma , Mo Wang , Xiaowen Liu\",\"doi\":\"10.1016/j.retram.2026.103570\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Neutrophils extracellular traps (NETs), released by neutrophils, play a core role in the occurrence and development of atherosclerosis (AS) lesions, which components damage endothelium, destabilize plaques by inducing vascular smooth muscle cell death, and exacerbate inflammation and thrombosis via interactions with phagocytes, platelets, and T cells. By blocking the production pathway of NETs and degrading the components of NETs are all feasible methods that could be explored to reduce AS. Here, we reviewed the NETs’ role in AS and their therapeutic potential, offering clinical translation insights.</div></div>\",\"PeriodicalId\":54260,\"journal\":{\"name\":\"Current Research in Translational Medicine\",\"volume\":\"74 1\",\"pages\":\"Article 103570\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2026-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Research in Translational Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452318626000073\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2026/2/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research in Translational Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452318626000073","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

由中性粒细胞释放的中性粒细胞胞外陷阱（NETs）在动脉粥样硬化（AS）病变的发生和发展中起核心作用，其成分破坏内皮，通过诱导血管平滑肌细胞死亡使斑块不稳定，并通过与吞噬细胞、血小板和T细胞的相互作用加剧炎症和血栓形成。阻断net的生成途径和降解net的组分都是降低AS的可行方法。在这里，我们回顾了NETs在AS中的作用及其治疗潜力，提供了临床翻译见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The effect of neutrophil extracellular traps in atherosclerosis

Neutrophils extracellular traps (NETs), released by neutrophils, play a core role in the occurrence and development of atherosclerosis (AS) lesions, which components damage endothelium, destabilize plaques by inducing vascular smooth muscle cell death, and exacerbate inflammation and thrombosis via interactions with phagocytes, platelets, and T cells. By blocking the production pathway of NETs and degrading the components of NETs are all feasible methods that could be explored to reduce AS. Here, we reviewed the NETs’ role in AS and their therapeutic potential, offering clinical translation insights.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Research in Translational Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

7.00

自引率

4.90%

发文量

审稿时长

45 days

期刊介绍： Current Research in Translational Medicine is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of hematology, immunology, infectiology, hematopoietic cell transplantation, and cellular and gene therapy. The journal considers for publication English-language editorials, original articles, reviews, and short reports including case-reports. Contributions are intended to draw attention to experimental medicine and translational research. Current Research in Translational Medicine periodically publishes thematic issues and is indexed in all major international databases (2017 Impact Factor is 1.9). Core areas covered in Current Research in Translational Medicine are: Hematology, Immunology, Infectiology, Hematopoietic, Cell Transplantation, Cellular and Gene Therapy.