口咽吞咽困难与特发性炎性肌病亚组之间的关系：一项横断面研究。

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Dysphagia Pub Date : 2026-08-01 Epub Date: 2026-02-21 DOI:10.1007/s00455-026-10932-9

Monica Segura-Hernandez, Luis Fernando Galindo-Borbón, Miguel Ángel Pérez-Rodriguez

引用次数: 0

摘要

口咽吞咽困难（OD）在特发性炎症性肌病（IIM）中经常观察到，但其严重程度和不同亚型的分布数据仍不一致。本研究考察了OD与三个主要IIM亚组：皮肌炎（DM）、多发性肌炎（PM）和包涵体肌炎（IBM）之间的关系，重点关注吞咽损伤的严重程度和吸入事件的潜在风险。在前瞻性横断面分析中，对74名符合Bohan/Peter或EULAR/ACR IIM标准的患者进行了评估。所有患者均行软性内镜下吞咽检查（FEES），有多种稠度（布丁、花蜜、液体、固体）。使用标准化量表对吞咽困难的严重程度进行分级。在调整年龄和性别后，Logistic回归评估疾病亚型是否预测中度至重度吞咽困难。皮肌炎更常与中度至重度OD相关，而不是PM或IBM。FEES检查结果显示各组间咽相功能障碍有显著差异，尤其是后溢、咽残留和喉部穿透。Logistic回归发现DM是中度至重度吞咽困难的唯一独立预测因子（OR = 0.09, 95% CI 0.01-0.82, p = 0.03）。虽然广泛报道IBM患者表现出明显的吞咽困难，但该队列中IBM病例的数量较少（n = 5）限制了明确的推断。在该样本中，皮肌炎是与严重吞咽功能障碍相关的主要亚型，这表明需要对糖尿病进行早期吞咽困难筛查和有针对性的治疗。未来有必要对更大的IBM样本和纵向设计进行研究，以验证这些发现并完善治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dysphagia 医学-耳鼻喉科学

CiteScore

4.90

自引率

15.40%

发文量

149

审稿时长

6-12 weeks

期刊介绍： Dysphagia aims to serve as a voice for the benefit of the patient. The journal is devoted exclusively to swallowing and its disorders. The purpose of the journal is to provide a source of information to the flourishing dysphagia community. Over the past years, the field of dysphagia has grown rapidly, and the community of dysphagia researchers have galvanized with ambition to represent dysphagia patients. In addition to covering a myriad of disciplines in medicine and speech pathology, the following topics are also covered, but are not limited to: bio-engineering, deglutition, esophageal motility, immunology, and neuro-gastroenterology. The journal aims to foster a growing need for further dysphagia investigation, to disseminate knowledge through research, and to stimulate communication among interested professionals. The journal publishes original papers, technical and instrumental notes, letters to the editor, and review articles.