PtNPs@GQDs纳米复合材料的设计与合成及其对结直肠癌的抗癌作用

IF 5.2 3区材料科学 Q2 MATERIALS SCIENCE, COATINGS & FILMS

Diamond and Related Materials Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI:10.1016/j.diamond.2026.113389

HuiLong Xie , YongQin Wei , JiaNi Xiong , ChengYan Wang , GuoCong Guo , JieMing Xie

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引用次数: 0

摘要

以铂为基础的结直肠癌化疗由于严重的肾毒性和耐药性而受到限制。为了解决这个问题，我们合成了一种新型的铂纳米粒子-石墨烯量子点纳米结构（PtNPs@GQDs），具有优异的水溶性，稳定性和高催化/还原活性。在体外，PtNPs@GQDs在低铂浓度（<1.6 μg Pt/mL）下对结肠癌细胞有明显的生长抑制作用，并显著诱导细胞凋亡。在体内，PtNPs@GQDs（8.2和12.4 mg Pt/kg）显著抑制HT-29异种移植小鼠的肿瘤生长。这些发现突出了PtNPs@GQDs作为一种有前景的结直肠癌新化疗药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design and synthesis of a PtNPs@GQDs nanocomposites and its anticancer effects on colorectal cancer

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Design and synthesis of a PtNPs@GQDs nanocomposites and its anticancer effects on colorectal cancer

Platinum-based chemotherapy for colorectal cancer is limited by severe nephrotoxicity and drug resistance. To address this, we synthesized a novel platinum nanoparticle-graphene quantum dot nanostructure (PtNPs@GQDs), characterized by excellent water solubility, stability, and high catalytic/reductive activity. In vitro, PtNPs@GQDs demonstrated potent growth inhibition of colon cancer cells at low platinum concentrations (<1.6 μg Pt/mL) and significantly induced apoptosis. In vivo, PtNPs@GQDs (8.2 and 12.4 mg Pt/kg) markedly suppressed tumor growth in HT-29 xenograft mice. These findings highlight PtNPs@GQDs as a promising new chemotherapeutic agent for colorectal cancer.

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来源期刊

Diamond and Related Materials 工程技术-材料科学：综合

CiteScore

6.00

自引率

14.60%

发文量

702

审稿时长

2.1 months

期刊介绍： DRM is a leading international journal that publishes new fundamental and applied research on all forms of diamond, the integration of diamond with other advanced materials and development of technologies exploiting diamond. The synthesis, characterization and processing of single crystal diamond, polycrystalline films, nanodiamond powders and heterostructures with other advanced materials are encouraged topics for technical and review articles. In addition to diamond, the journal publishes manuscripts on the synthesis, characterization and application of other related materials including diamond-like carbons, carbon nanotubes, graphene, and boron and carbon nitrides. Articles are sought on the chemical functionalization of diamond and related materials as well as their use in electrochemistry, energy storage and conversion, chemical and biological sensing, imaging, thermal management, photonic and quantum applications, electron emission and electronic devices. The International Conference on Diamond and Carbon Materials has evolved into the largest and most well attended forum in the field of diamond, providing a forum to showcase the latest results in the science and technology of diamond and other carbon materials such as carbon nanotubes, graphene, and diamond-like carbon. Run annually in association with Diamond and Related Materials the conference provides junior and established researchers the opportunity to exchange the latest results ranging from fundamental physical and chemical concepts to applied research focusing on the next generation carbon-based devices.