炎症指数与急性深静脉血栓形成及血栓负荷的关系。

IF 2.6 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart & Lung Pub Date : 2026-07-01 Epub Date: 2026-02-10 DOI:10.1016/j.hrtlng.2026.102737

Yifei Bai , Da Li , Xin Huang , Kai Wang , Zhongzhi Jia , Hui Qin , Aijiao Lu

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引用次数: 0

摘要

背景：炎症是静脉血栓形成的关键。全血细胞计数（CBC）衍生的炎症指标是新兴的生物标志物，但其在诊断急性深静脉血栓形成（DVT）和血栓负担分层中的价值有待进一步研究。目的：评价cbc衍生炎症指标——中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）、淋巴细胞与单核细胞比值（LMR）和全身炎症反应指数（SIRI）对急性DVT诊断和血栓负荷分层的价值。方法：回顾性分析360例行静脉多普勒超声检查的患者，将其分为非DVT组（200例）、孤立性远端DVT组（114例）和近端DVT组（46例）。收集人口统计数据、合并症和CBC参数来计算指数。采用受试者工作特征（ROC）曲线分析评估预测能力，采用Kruskal-Wallis和Dunn检验评估组间差异。结果：急性DVT患者NLR、PLR、SII、SIRI明显升高，LMR明显降低。ROC分析显示LMR对急性DVT的预测效果最高（AUC: 0.737），特异性高（85.5%）。在区分IDDVT和PDVT时，只有NLR和LMR具有显著的鉴别价值。结论：NLR和LMR是诊断急性DVT和评估血栓负荷的有价值的生物标志物。它们的高特异性支持在风险分层中辅助使用，但其低敏感性需要与综合临床评估相结合。

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Association between inflammation‑based index and acute deep vein thrombosis and thrombus burden

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Association between inflammation‑based index and acute deep vein thrombosis and thrombus burden

Background

Inflammation is pivotal in venous thrombogenesis. Complete blood count (CBC)-derived inflammation indexes are emerging biomarkers, but their value for diagnosing acute deep vein thrombosis (DVT) and stratifying thrombus burden requires further investigation.

Objective

To evaluate CBC-derived inflammation indexes—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), lymphocyte-to-monocyte ratio (LMR), and systemic inflammation response index (SIRI)—for diagnosing acute DVT and stratifying thrombus burden.

Methods

In this retrospective study, 360 patients referred for venous Doppler ultrasound were categorized into non-DVT (n = 200), isolated distal DVT (IDDVT, n = 114), and proximal DVT (PDVT, n = 46) groups. Demographic data, comorbidities, and CBC parameters were collected to calculate the indexes. Predictive ability was assessed using receiver operating characteristic (ROC) curve analysis, and group differences were evaluated with the Kruskal-Wallis and Dunn's tests.

Results

Acute DVT patients showed significantly elevated NLR, PLR, SII, and SIRI, and reduced LMR. ROC analysis indicated LMR had the highest predictive efficacy for acute DVT (AUC: 0.737) with high specificity (85.5%). For distinguishing IDDVT from PDVT, only NLR and LMR showed significant discriminative value.

Conclusion

NLR and LMR are valuable biomarkers for diagnosing acute DVT and assessing thrombus burden. Their high specificity supports adjunctive use in risk stratification, but their low sensitivity necessitates integration with comprehensive clinical assessment.

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来源期刊

Heart & Lung 医学-呼吸系统

CiteScore

4.60

自引率

3.60%

发文量

184

审稿时长

35 days

期刊介绍： Heart & Lung: The Journal of Cardiopulmonary and Acute Care, the official publication of The American Association of Heart Failure Nurses, presents original, peer-reviewed articles on techniques, advances, investigations, and observations related to the care of patients with acute and critical illness and patients with chronic cardiac or pulmonary disorders. The Journal''s acute care articles focus on the care of hospitalized patients, including those in the critical and acute care settings. Because most patients who are hospitalized in acute and critical care settings have chronic conditions, we are also interested in the chronically critically ill, the care of patients with chronic cardiopulmonary disorders, their rehabilitation, and disease prevention. The Journal''s heart failure articles focus on all aspects of the care of patients with this condition. Manuscripts that are relevant to populations across the human lifespan are welcome.