{"title":"植物胁迫激活的微生物天然产物。","authors":"Barbara I. Adaikpoh","doi":"10.1039/D5NP00062A","DOIUrl":null,"url":null,"abstract":"<p>Covering: 2000 to August 2025</p><p>The search for new antimicrobial natural products from microorganisms has been limited by the transcriptional silencing of biosynthetic genes when microbes are cultivated outside their ecological environments. Nevertheless, applying knowledge of the ecological roles, for example, microbial defense against plant pathogens, can improve drug discovery efforts. Interactions between plants and their microbiota, during adaptation to pathogen stress, provide ecological cues that induce microenvironments suppressive to pathogens. This article highlights research linking pathogen-induced plant stress signals to the activation of microbial natural product biosynthesis, emphasizing the need for further studies on how plant metabolites can influence biosynthesis in plant-associated microbes.</p>","PeriodicalId":94,"journal":{"name":"Natural Product Reports","volume":" 4","pages":" 590-596"},"PeriodicalIF":12.5000,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/np/d5np00062a?page=search","citationCount":"0","resultStr":"{\"title\":\"Microbial natural products activated by plant stress\",\"authors\":\"Barbara I. Adaikpoh\",\"doi\":\"10.1039/D5NP00062A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Covering: 2000 to August 2025</p><p>The search for new antimicrobial natural products from microorganisms has been limited by the transcriptional silencing of biosynthetic genes when microbes are cultivated outside their ecological environments. Nevertheless, applying knowledge of the ecological roles, for example, microbial defense against plant pathogens, can improve drug discovery efforts. Interactions between plants and their microbiota, during adaptation to pathogen stress, provide ecological cues that induce microenvironments suppressive to pathogens. This article highlights research linking pathogen-induced plant stress signals to the activation of microbial natural product biosynthesis, emphasizing the need for further studies on how plant metabolites can influence biosynthesis in plant-associated microbes.</p>\",\"PeriodicalId\":94,\"journal\":{\"name\":\"Natural Product Reports\",\"volume\":\" 4\",\"pages\":\" 590-596\"},\"PeriodicalIF\":12.5000,\"publicationDate\":\"2026-02-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2026/np/d5np00062a?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Reports\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2026/np/d5np00062a\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Reports","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2026/np/d5np00062a","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Microbial natural products activated by plant stress
Covering: 2000 to August 2025
The search for new antimicrobial natural products from microorganisms has been limited by the transcriptional silencing of biosynthetic genes when microbes are cultivated outside their ecological environments. Nevertheless, applying knowledge of the ecological roles, for example, microbial defense against plant pathogens, can improve drug discovery efforts. Interactions between plants and their microbiota, during adaptation to pathogen stress, provide ecological cues that induce microenvironments suppressive to pathogens. This article highlights research linking pathogen-induced plant stress signals to the activation of microbial natural product biosynthesis, emphasizing the need for further studies on how plant metabolites can influence biosynthesis in plant-associated microbes.
期刊介绍：
Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis.
With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results.
NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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