面瘫中草药汤剂的安全性：国家医保数据库的粗化精确匹配分析

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2026-06-01 Epub Date: 2025-11-26 DOI:10.1016/j.imr.2025.101279

Yongjoo Kim , Nan-He Yoon , Soobin Jang , Kyeore Bae , Wonkyung Moon , Minjung Park , Sujin Kim

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引用次数: 0

摘要

草药煎剂（HMD）是治疗贝尔氏麻痹（BP）的潜在方法，但有关其安全性的实际证据有限。本研究调查了HMD用于治疗BP是否与不良事件风险相关，该研究使用了韩国一个基于索赔的全国性数据库。方法回顾性队列研究使用韩国健康保险审查和评估数据库的数据。我们采用粗化精确匹配，将1627名在2020年11月至2022年2月期间至少服用过一次HMD处方的BP患者与1627名未使用HMD的BP患者进行匹配。差异中差异逻辑回归模型比较了HMD使用者和非使用者之间安全结局的发生率。结果：处方后3、6、9和11个月，HMD使用者和未使用HMD的BP患者在肝毒性、肾衰竭、过敏事件、住院和急诊就诊的风险方面没有观察到显著差异。所有的效应估计值和相应的95%置信区间都包括零值。结论HMD使用者与非使用者BP患者的安全结局风险无显著差异。进一步的研究是必要的，以了解具体的草药配方的安全性或个别草药使用更广泛的安全措施。

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Safety of herbal medicine decoction for facial palsy: Coarsened exact matching analysis of the national health insurance database

Background

Herbal medicine decoctions (HMD) are potential treatments for Bell’s palsy (BP), but real-world evidence regarding the safety is limited. This study investigated whether HMD use for BP was associated with risk of adverse events using a nationwide claims-based database in South Korea.

Methods

This retrospective cohort study used data from the Korean Health Insurance Review and Assessment database. We applied coarsened exact matching, through which 1627 BP patients who received at least one HMD prescription between November 2020 and February 2022 were matched with 1627 BP patients who did not use HMD. Difference-in-differences logistic regression modeling compared the incidences of safety outcomes between HMD users and non-users.

Results

No significant differences were observed in the risk of hepatotoxicity, renal failure, allergic events, hospitalization, and emergency department visits between HMD users and non-users with BP, assessed at 3, 6, 9 and 11 months after HMD prescription. All effect estimates and corresponding 95 % confidence intervals included the null value.

Conclusions

There was no significant difference in the risk of safety outcomes between HMD users and non-users with BP. Further research is warranted to understand the safety of specific herbal formulas or individual herbs using broader safety measures.

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.