tpgs修饰脂质体姜提取物对大鼠醋酸性溃疡性结肠炎的治疗作用。

IF 4.6 2区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2026-03-01 Epub Date: 2026-01-19 DOI:10.1016/j.nano.2026.102903

Zakieh Keshavarzi , Sonia Fathi-karkan , Ali Siahposht- Khachaki , Reza Kheirandish , Mohammad Hadi Nematollahi , Mohammad Amin Rajizadeh

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引用次数: 0

摘要

背景：溃疡性结肠炎（UC）是一种长期的炎症性肠病，引起粘膜损伤和氧化应激。天然物质，如生姜提取物，已知具有抗炎和抗氧化作用。然而，生姜提取物等活性成分的临床有效性受到其低生物利用度的限制。脂质体给药系统，特别是用D-α-生育酚聚乙二醇琥珀酸酯（TPGS）修饰的脂质体，可以提高生姜的稳定性和吸收，使其成为更有效的药用药物。由于普通生姜提取物的治疗效果不太好，因此开发和测试新的药物输送系统（如tpgs修饰脂质体）以提高UC治疗的效果至关重要。方法：选用雄性大鼠54只，随机分为9组，每组数量 = 6只。用含4%醋酸溶液灌肠诱导大鼠结肠炎。结肠炎诱导后第4天，大鼠腹腔注射100和300 mg/kg酒精姜提取物的简单、脂质体和tpgs修饰脂质体，持续5天。结果：本研究结果表明，给予脂质体形式的姜提取物可降低TNFα （P ）。结论：总体而言，本研究表明UC后，结肠炎症和氧化应激高于健康动物。此外，本研究结果表明，与简单形式相比，脂质体和tpgs修饰的脂质体能够发挥强大的抗炎和抗氧化作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The effects of TPGS-modified liposomal ginger extract in the treatment of acetic acid-induced ulcerative colitis in rats

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The effects of TPGS-modified liposomal ginger extract in the treatment of acetic acid-induced ulcerative colitis in rats

Background

Ulcerative colitis (UC) is a long-term inflammatory bowel disease that causes damage to the mucosa and oxidative stress. Natural substances, such as ginger extract, are known to have anti-inflammatory and antioxidant effects. However, the clinical effectiveness of active ingredients like ginger extract is limited by their low bioavailability. Liposomal drug delivery systems, especially those modified with D-α-tocopheryl polyethylene glycol succinate (TPGS), may enhance the stability and absorption of ginger, making it more effective as a medicinal agent. Since regular ginger extract doesn't work very well as a treatment, it's essential to develop and test new drug delivery systems, such as TPGS-modified liposomes, to enhance the outcomes of UC treatment.

Methods

A total of 54 male rats were utilized, randomly allocated into nine groups (number in each group = 6). Colitis was induced in rats through enemas containing a 4% solution of acetic acid. Four days post-induction of colitis, rats were administered simple, liposomal, and TPGS-modified liposomal forms of 100 and 300 mg/kg of alcoholic ginger extract intraperitoneally for five days.

Results

The results of this study showed that administration of liposomal forms of ginger extract reduced TNFα (P < 0.001) and IL6 (P < 0.001) levels in the colon tissue of rats. These compounds also increased SOD and catalase activity in the colon tissue and reduced NO levels. At the histological level, liposomal forms of ginger were also able to reduce tissue inflammation. Also, our results showed that the encapsulation efficiency of ginger extract was 73 ± 0.38%.

Conclusion

Overall, this research showed that following UC, the colon inflammation and oxidative stress were higher than the healthy animals. Also, the results of this study showed that administration of the liposomal and TPGS-modified liposome was able to exert strong anti-inflammatory and antioxidant effects compared to simple forms.

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来源期刊

Nanomedicine : nanotechnology, biology, and medicine 工程技术-纳米科技

CiteScore

11.10

自引率

0.00%

发文量

133

审稿时长

42 days

期刊介绍： The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.