{"title":"红斑狼疮对透析患者全因死亡率、心血管死亡率和感染相关死亡率的影响：冲绳透析研究登记处。","authors":"Nanako Oshiro, Yukiko Hasuike, Kentaro Kohagura, Kunitoshi Iseki","doi":"10.1002/1744-9987.70117","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE) and can lead to end-stage kidney disease (ESKD). We aimed to assess the relative mortality risk associated with SLE among dialysis patients.</p><p><strong>Methods: </strong>This retrospective longitudinal cohort study included all dialysis patients in the Okinawa Dialysis Study 30 registry. Cox proportional hazard models were performed to assess mortality.</p><p><strong>Results: </strong>Of 5246 patients, 111 had ESKD secondary to SLE. Compared with ESKD patients secondary to other causes, those with SLE had significantly higher risk of death (HR 2.55, 95% CI 1.81-3.47, p < 0.0001), cardiovascular death (HR 1.94, 95% CI 1.13-3.33, p = 0.0158), and infection death (HR 4.21, 95% CI 2.40-7.37, p < 0.0001) after adjusting for age, era of dialysis initiation, and sex.</p><p><strong>Conclusion: </strong>SLE may be independently associated with an increased risk of death in dialysis patients.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"340-344"},"PeriodicalIF":1.2000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Lupus on All-Cause, Cardiovascular, and Infection-Related Mortality Among Dialysis Patients: Okinawa Dialysis Study Registry.\",\"authors\":\"Nanako Oshiro, Yukiko Hasuike, Kentaro Kohagura, Kunitoshi Iseki\",\"doi\":\"10.1002/1744-9987.70117\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE) and can lead to end-stage kidney disease (ESKD). We aimed to assess the relative mortality risk associated with SLE among dialysis patients.</p><p><strong>Methods: </strong>This retrospective longitudinal cohort study included all dialysis patients in the Okinawa Dialysis Study 30 registry. Cox proportional hazard models were performed to assess mortality.</p><p><strong>Results: </strong>Of 5246 patients, 111 had ESKD secondary to SLE. Compared with ESKD patients secondary to other causes, those with SLE had significantly higher risk of death (HR 2.55, 95% CI 1.81-3.47, p < 0.0001), cardiovascular death (HR 1.94, 95% CI 1.13-3.33, p = 0.0158), and infection death (HR 4.21, 95% CI 2.40-7.37, p < 0.0001) after adjusting for age, era of dialysis initiation, and sex.</p><p><strong>Conclusion: </strong>SLE may be independently associated with an increased risk of death in dialysis patients.</p>\",\"PeriodicalId\":94253,\"journal\":{\"name\":\"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy\",\"volume\":\" \",\"pages\":\"340-344\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2026-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/1744-9987.70117\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2026/1/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/1744-9987.70117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
狼疮肾炎是系统性红斑狼疮（SLE）最严重的并发症之一，可导致终末期肾脏疾病（ESKD）。我们的目的是评估透析患者SLE相关的相对死亡风险。方法：这项回顾性纵向队列研究包括冲绳透析研究30登记的所有透析患者。采用Cox比例风险模型评估死亡率。结果：5246例患者中，111例为SLE继发ESKD。与继发于其他原因的ESKD患者相比，SLE患者的死亡风险明显更高（HR 2.55, 95% CI 1.81-3.47, p）。结论：SLE可能与透析患者死亡风险增加独立相关。
Impact of Lupus on All-Cause, Cardiovascular, and Infection-Related Mortality Among Dialysis Patients: Okinawa Dialysis Study Registry.
Introduction: Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE) and can lead to end-stage kidney disease (ESKD). We aimed to assess the relative mortality risk associated with SLE among dialysis patients.
Methods: This retrospective longitudinal cohort study included all dialysis patients in the Okinawa Dialysis Study 30 registry. Cox proportional hazard models were performed to assess mortality.
Results: Of 5246 patients, 111 had ESKD secondary to SLE. Compared with ESKD patients secondary to other causes, those with SLE had significantly higher risk of death (HR 2.55, 95% CI 1.81-3.47, p < 0.0001), cardiovascular death (HR 1.94, 95% CI 1.13-3.33, p = 0.0158), and infection death (HR 4.21, 95% CI 2.40-7.37, p < 0.0001) after adjusting for age, era of dialysis initiation, and sex.
Conclusion: SLE may be independently associated with an increased risk of death in dialysis patients.
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