葡萄糖给药对成年男女应激反应性和长期记忆的影响。

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2026-03-01 Epub Date: 2025-12-25 DOI:10.1016/j.psyneuen.2025.107741

Maria Meier , Christian J. Merz , Tobias Rüttgens , Oliver T. Wolf , Jens C. Pruessner

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引用次数: 0

摘要

压力和相关的皮质醇释放对长期记忆（LTM）有深远的影响。虽然葡萄糖增加了皮质醇应激反应，并在非应激情况下表现出增强记忆的作用，但葡萄糖和应激对LTM的相互作用很少被研究。本研究的目的是探讨葡萄糖相关的皮质醇应激反应的放大是否会促进LTM的形成。总体而言，N = 62名健康、禁食的成年人（年龄M = 23.13, SD = 3.02； 54.84%为女性）参与了研究。他们喝了一杯含有水或葡萄糖的饮料，并进行了一项无压力的控制任务或特里尔物体社会压力测试，在此过程中，小组成员与某些物体（中心）互动，而不触及其他物体（外围）。在估计的皮质醇峰值处，他们编码了一个单词表。第二天，他们取回了物品和单词。我们反复评估主观压力、唾液皮质醇和血糖浓度，并记录心电图。葡萄糖增加了血糖浓度，与控制任务相比，应激源导致皮质醇显著增加。与水组相比，葡萄糖组皮质醇的变化更为明显。与水组相比，葡萄糖组在恢复期间心率升高。当在压力下编码时，中心物体比外围物体更容易被记住。此外，与中性词汇相比，情感词汇的记忆效果更好。这些作用不受葡萄糖的调节。这些发现表明，与压力和葡萄糖摄入量无关的情绪信息比中性信息更容易被记住。应激增强应激源相关信息的LTM，葡萄糖摄入增加皮质醇应激反应。然而，这些因素似乎并不相互作用。因此，在记忆压力事件时，葡萄糖的可用性可能起着不那么决定性的作用。

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The influence of glucose administration on stress reactivity and long-term memory in adult men and women

Stress and the associated cortisol release have profound effects on long-term memory (LTM). While glucose increases the cortisol stress response and exhibits memory enhancing effects in non-stressful situations, the interaction of glucose and stress on LTM has rarely been studied. The aim of this study was to investigate whether the glucose-related amplification of the cortisol stress response would enhance LTM formation. Overall, N = 62 healthy, fasted adults (age M = 23.13, SD = 3.02; 54.84 % female) participated. They consumed a drink containing water or glucose and underwent a non-stressful control task or the Trier Social Stress Test with Objects, during which panel members interact with certain objects (central) while leaving others untouched (peripheral). At the estimated cortisol peak, they encoded a wordlist. On the next day, they retrieved the objects and the words. We repeatedly assessed subjective stress, salivary cortisol and blood glucose concentrations and recorded an electrocardiogram. Glucose increased blood glucose concentrations, and the stressor led to a significant increase in cortisol as compared with the control task. Changes in cortisol were more pronounced in the glucose as compared with the water groups. Heart rate was elevated in the glucose as compared with the water groups during the recovery. Central objects were better remembered than peripheral objects when encoded during stress. Additionally, emotional words were remembered better as compared with neutral words. These effects were not modulated by glucose. These findings suggest that emotional information is remembered better than neutral information independent of stress and glucose intake. Stress enhances LTM of stressor-relevant information and glucose intake increases the cortisol stress response. However, these factors do not appear to interact. Glucose availability may thus play a less decisive role when memorizing a stressful episode.

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.