慢性感染的机制：隐球菌的多重策略

IF 4.6 2区生物学 Q1 MYCOLOGY

Fungal Biology Reviews Pub Date : 2026-03-01 Epub Date: 2025-12-10 DOI:10.1016/j.fbr.2025.100469

Sijie Qian, Danfeng Fang, Hongxin Fu, Wei Wu, Weibo Du

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引用次数: 0

摘要

隐球菌是一种机会致病性真菌，能够通过多种复杂的机制在宿主体内建立慢性感染：通过泰坦细胞和休眠的持久性/VBNC细胞定殖生态位；寄主通过胶囊介导的免疫逃避和对温度和CO2的生理耐受来适应；组织传播由酶降解和种子细胞繁殖支持。这篇综述综合了这些相互关联的途径，为理解隐球菌的持久性提供了一个全面的框架，并确定了治疗干预的有希望的靶点。

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Mechanisms of chronic infection: The multificated strategy of Cryptococcus

Cryptococcus is an opportunistic pathogenic fungus that is capable of establishing chronic infections in hosts through diverse and intricate mechanisms: niche colonization via Titan cells and dormant persister/VBNC cells; host adaptation through capsule mediated immune evasion and phsiological tolerance to temperature and CO2; and tissue dissemination supported by enzymatic degradation and seed cell propagation. This review synthesizes these interconnected pathways to provide a comprehensive framework for understanding cryptococcal persistence and identifies promising targets for therapeutic intervention.

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来源期刊

Fungal Biology Reviews MYCOLOGY-

CiteScore

10.60

自引率

0.00%

发文量

期刊介绍： Fungal Biology Reviews is an international reviews journal, owned by the British Mycological Society. Its objective is to provide a forum for high quality review articles within fungal biology. It covers all fields of fungal biology, whether fundamental or applied, including fungal diversity, ecology, evolution, physiology and ecophysiology, biochemistry, genetics and molecular biology, cell biology, interactions (symbiosis, pathogenesis etc), environmental aspects, biotechnology and taxonomy. It considers aspects of all organisms historically or recently recognized as fungi, including lichen-fungi, microsporidia, oomycetes, slime moulds, stramenopiles, and yeasts.