二甲双胍和睾酮替代疗法对老年男性激素相关癌症和无癌症人群的心血管影响

IF 3.6 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Epidemiology Pub Date : 2026-01-01 Epub Date: 2025-12-05 DOI:10.1016/j.annepidem.2025.12.004

Omer Abdelgadir , Salome W. Njoroge , Anirudh S. Babu , Md Ibrahim Tahashilder , Jesus Gibran Hernandez-Perez , Luisa E. Torres-Sanchez , Maryam R. Hussain , Alejandro Villasante-Tezanos , Ioannis Malagaris , Wissam I. Khalife , Yong-Fang Kuo , David S. Lopez

{"title":"二甲双胍和睾酮替代疗法对老年男性激素相关癌症和无癌症人群的心血管影响","authors":"Omer Abdelgadir , Salome W. Njoroge , Anirudh S. Babu , Md Ibrahim Tahashilder , Jesus Gibran Hernandez-Perez , Luisa E. Torres-Sanchez , Maryam R. Hussain , Alejandro Villasante-Tezanos , Ioannis Malagaris , Wissam I. Khalife , Yong-Fang Kuo , David S. Lopez","doi":"10.1016/j.annepidem.2025.12.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>This study examines the association between use of metformin and testosterone replacement therapy (TTh) with risk of cardiovascular disease (CVD) and its subcategories in the overall population, hormone-related cancer (HRC) survivors, and cancer-free population.</div></div><div><h3>Methods</h3><div>A retrospective cohort of 58,028 men ≥ 65 years was identified using SEER-Medicare 2007–2015 data. Metformin and TTh prescriptions were ascertained for this analysis. The primary outcome was incident composite CVD and CVD subcategories (heart failure [HF], ischemic heart disease [IHD], peripheral arterial disease [PAD], and stroke). Multivariable time-dependent Cox proportional hazard models were conducted.</div></div><div><h3>Results</h3><div>Metformin use was inversely associated with CVD in the overall population (Hazard Ratio [HR] = 0.72, 95 % CI, 0.68 – 0.76), cancer-free population (HR = 0.72, 95 % CI, 0.68 – 0.76), and HRC survivors (HR = 0.67, 95 % CI, 0.64 – 0.73). Likewise, TTh use was inversely associated with CVD in overall population (HR = 0.82, 95 % CI, 0.67 – 0.99), cancer-free population (HR = 0.80, 95 % CI, 0.64 – 0.99), and HRC survivors (HR = 0.64, 95 % CI, 0.48 – 86).</div></div><div><h3>Conclusions</h3><div>Metformin and TTh were inversely associated with CVD among older men in the overall population, HRC survivors, and cancer-free populations. Metformin users showed the greatest CVD risk reduction. Further studies are warranted to confirm these associations.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"113 ","pages":"Pages 38-46"},"PeriodicalIF":3.6000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cardiovascular effects of metformin and testosterone replacement therapy in older men with hormone-related cancers and cancer-free population\",\"authors\":\"Omer Abdelgadir , Salome W. Njoroge , Anirudh S. Babu , Md Ibrahim Tahashilder , Jesus Gibran Hernandez-Perez , Luisa E. Torres-Sanchez , Maryam R. Hussain , Alejandro Villasante-Tezanos , Ioannis Malagaris , Wissam I. Khalife , Yong-Fang Kuo , David S. Lopez\",\"doi\":\"10.1016/j.annepidem.2025.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>This study examines the association between use of metformin and testosterone replacement therapy (TTh) with risk of cardiovascular disease (CVD) and its subcategories in the overall population, hormone-related cancer (HRC) survivors, and cancer-free population.</div></div><div><h3>Methods</h3><div>A retrospective cohort of 58,028 men ≥ 65 years was identified using SEER-Medicare 2007–2015 data. Metformin and TTh prescriptions were ascertained for this analysis. The primary outcome was incident composite CVD and CVD subcategories (heart failure [HF], ischemic heart disease [IHD], peripheral arterial disease [PAD], and stroke). Multivariable time-dependent Cox proportional hazard models were conducted.</div></div><div><h3>Results</h3><div>Metformin use was inversely associated with CVD in the overall population (Hazard Ratio [HR] = 0.72, 95 % CI, 0.68 – 0.76), cancer-free population (HR = 0.72, 95 % CI, 0.68 – 0.76), and HRC survivors (HR = 0.67, 95 % CI, 0.64 – 0.73). Likewise, TTh use was inversely associated with CVD in overall population (HR = 0.82, 95 % CI, 0.67 – 0.99), cancer-free population (HR = 0.80, 95 % CI, 0.64 – 0.99), and HRC survivors (HR = 0.64, 95 % CI, 0.48 – 86).</div></div><div><h3>Conclusions</h3><div>Metformin and TTh were inversely associated with CVD among older men in the overall population, HRC survivors, and cancer-free populations. Metformin users showed the greatest CVD risk reduction. Further studies are warranted to confirm these associations.</div></div>\",\"PeriodicalId\":50767,\"journal\":{\"name\":\"Annals of Epidemiology\",\"volume\":\"113 \",\"pages\":\"Pages 38-46\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2026-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Epidemiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1047279725003527\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/12/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1047279725003527","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

摘要

目的：本研究探讨了在总体人群、激素相关癌症（HRC）幸存者和无癌症人群中，二甲双胍和睾酮替代疗法（TTh）与心血管疾病（CVD）及其亚类风险之间的关系。方法：采用2007-2015年SEER-Medicare数据，对58028名≥65岁的男性进行回顾性队列研究。本分析确定了二甲双胍和TTh处方。主要结局是复合心血管疾病和心血管疾病亚类别（心力衰竭[HF]、缺血性心脏病[IHD]、外周动脉疾病[PAD]和中风）的发生率。采用多变量时变Cox比例风险模型。结果：二甲双胍的使用与总体人群（风险比[HR] = 0.72, 95% CI, 0.68 - 0.76）、无癌人群（HR = 0.72, 95% CI, 0.68 - 0.76）和HRC幸存者（HR = 0.67, 95% CI, 0.64 - 0.73）的心血管疾病呈负相关。同样，在总体人群（HR = 0.82, 95% CI, 0.67 - 0.99）、无癌人群（HR = 0.80, 95% CI, 0.64 - 0.99）和HRC幸存者（HR = 0.64, 95% CI, 0.48 - 86）中，TTh的使用与CVD呈负相关。结论：在总体人群、HRC幸存者和无癌人群的老年男性中，二甲双胍和th与CVD呈负相关。二甲双胍使用者心血管疾病风险降低幅度最大。需要进一步的研究来证实这些关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cardiovascular effects of metformin and testosterone replacement therapy in older men with hormone-related cancers and cancer-free population

Purpose

This study examines the association between use of metformin and testosterone replacement therapy (TTh) with risk of cardiovascular disease (CVD) and its subcategories in the overall population, hormone-related cancer (HRC) survivors, and cancer-free population.

Methods

A retrospective cohort of 58,028 men ≥ 65 years was identified using SEER-Medicare 2007–2015 data. Metformin and TTh prescriptions were ascertained for this analysis. The primary outcome was incident composite CVD and CVD subcategories (heart failure [HF], ischemic heart disease [IHD], peripheral arterial disease [PAD], and stroke). Multivariable time-dependent Cox proportional hazard models were conducted.

Results

Metformin use was inversely associated with CVD in the overall population (Hazard Ratio [HR] = 0.72, 95 % CI, 0.68 – 0.76), cancer-free population (HR = 0.72, 95 % CI, 0.68 – 0.76), and HRC survivors (HR = 0.67, 95 % CI, 0.64 – 0.73). Likewise, TTh use was inversely associated with CVD in overall population (HR = 0.82, 95 % CI, 0.67 – 0.99), cancer-free population (HR = 0.80, 95 % CI, 0.64 – 0.99), and HRC survivors (HR = 0.64, 95 % CI, 0.48 – 86).

Conclusions

Metformin and TTh were inversely associated with CVD among older men in the overall population, HRC survivors, and cancer-free populations. Metformin users showed the greatest CVD risk reduction. Further studies are warranted to confirm these associations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

1.80%

发文量

207

审稿时长

59 days

期刊介绍： The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.