利福霉素对人吞噬细胞的体外和体外影响。

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1987-12-01

C Bersani, R Bertoletti, M L Colombo, C Merlini, M Uccelli, A Fietta, G Gialdroni Grassi

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引用次数: 0

摘要

我们研究了利福霉素SV、利福平和利福喷丁对人白细胞功能的影响。利福霉素在其治疗水平范围内抑制体外中性粒细胞趋化，并显著影响利福霉素敏感的金黄色葡萄球菌在人单核细胞内的存活。这两种作用都与这些抗生素在吞噬细胞内的渗透有关。在离体研究中，对5名金黄色葡萄球菌杀灭缺陷的受试者口服600毫克利福平。在给药后150和210分钟，中性粒细胞趋化性显著降低，对金黄色葡萄球菌的活性增加。

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In vitro and ex vivo influence of rifamycins on human phagocytes.

We studied the effects of rifamycin SV, rifampicin and rifapentine on human phagocyte functions. Rifamycins inhibited in vitro neutrophil chemotaxis in the range of their therapeutic levels, and they significantly affected the survival of a rifamycin-sensitive strain of Staphylococcus aureus inside human monocytes. Both effects were related to the intraphagocytic penetration of these antibiotics. For the ex vivo studies, 600 mg of rifampicin were orally administered to five subjects with defective S. aureus killing. A significant reduction of neutrophil chemotaxis and increased activity against S. aureus were shown 150 and 210 min after administration of the drug.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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