监测和评估芬兰人口（NUGEN）中多溴联苯醚（PBDEs）和阻燃剂（decchlorane Plus和DBDPE）与父母生活方式因素的关系

IF 8.2 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Emerging Contaminants Pub Date : 2026-03-01 Epub Date: 2025-11-11 DOI:10.1016/j.emcon.2025.100596

Soha Salah , Päivi Myllynen , Petra Přibylová , Petr Kukučka , Liisa Laatio , Elina Sieppi , Maria Kummu , Saranya Palaniswamy , Khaled Abass

{"title":"监测和评估芬兰人口（NUGEN）中多溴联苯醚（PBDEs）和阻燃剂（decchlorane Plus和DBDPE）与父母生活方式因素的关系","authors":"Soha Salah , Päivi Myllynen , Petra Přibylová , Petr Kukučka , Liisa Laatio , Elina Sieppi , Maria Kummu , Saranya Palaniswamy , Khaled Abass","doi":"10.1016/j.emcon.2025.100596","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Human exposure to flame retardants, particularly PBDEs, is detectable in maternal plasma and linked to various adverse health outcomes, but the influence of parental lifestyle and diet on these levels remains poorly understood.</div></div><div><h3>Objective</h3><div>To monitor PBDEs in maternal and cord plasma samples and examine their relationships with parental health determinants - specifically dietary intake, environmental exposure, and lifestyle factors-in a Northern Finland population for the first time.</div></div><div><h3>Methods</h3><div>Maternal and cord plasma samples from 102 NUGEN cohort pairs were collected during caesarean sections at Oulu University Hospital. Plasma samples were analysed for PBDE congeners (BDE-47, BDE-66, BDE-85, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, BDE-209), DBDPE, and chlorinated flame retardants (sDP, aDP), with lipid adjustment. Total cord BFRs were calculated as the sum of all congeners quantified in cord plasma, and total maternal BFRs were calculated analogously using maternal plasma.</div></div><div><h3>Results</h3><div>PBDE congeners with the highest detection frequencies were maternal BDE-28 (42 %), BDE-47 (42 %), BDE-153 (100 %); and cord BDE-28 (50 %), BDE-47 (52 %), BDE-153 (95 %), BDE-154 (33 %). Maternal smoking was inversely associated with cord BDE-28 (−0.80 [−1.50, −0.09]). Higher paternal education was negatively associated with cord BDE-28 (−0.93 [−1.58, −0.27]), BDE-153 (−0.21 [−0.43, −0.005]), and BDE-154 (−4.34 [−8.00, −0.68]). High vegetable intake was inversely associated with cord BDE-154 (−3.99 [−7.76, −0.22]), while high meat intake was positively associated with total cord BFRs (0.42 [0.06, 0.78]), cord BDE-47 (0.67 [0.13, 1.21]), and maternal BDE-47 (0.77 [0.16, 1.37]).</div></div><div><h3>Conclusion</h3><div>PBDE levels were higher in cord than maternal samples but lower than in other European countries. Findings support maternal-to-child PBDE transfer and reveal associations with lifestyle, diet, and sociodemographic factors, including paternal variables-a notable gap in prior research.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"12 1","pages":"Article 100596"},"PeriodicalIF":8.2000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Monitoring and assessing the association of polybrominated diphenyl ethers (PBDEs) and flame retardants (Dechlorane Plus and DBDPE) with parental lifestyle factors in a mother–child cohort of the Finnish population (NUGEN)\",\"authors\":\"Soha Salah , Päivi Myllynen , Petra Přibylová , Petr Kukučka , Liisa Laatio , Elina Sieppi , Maria Kummu , Saranya Palaniswamy , Khaled Abass\",\"doi\":\"10.1016/j.emcon.2025.100596\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Human exposure to flame retardants, particularly PBDEs, is detectable in maternal plasma and linked to various adverse health outcomes, but the influence of parental lifestyle and diet on these levels remains poorly understood.</div></div><div><h3>Objective</h3><div>To monitor PBDEs in maternal and cord plasma samples and examine their relationships with parental health determinants - specifically dietary intake, environmental exposure, and lifestyle factors-in a Northern Finland population for the first time.</div></div><div><h3>Methods</h3><div>Maternal and cord plasma samples from 102 NUGEN cohort pairs were collected during caesarean sections at Oulu University Hospital. Plasma samples were analysed for PBDE congeners (BDE-47, BDE-66, BDE-85, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, BDE-209), DBDPE, and chlorinated flame retardants (sDP, aDP), with lipid adjustment. Total cord BFRs were calculated as the sum of all congeners quantified in cord plasma, and total maternal BFRs were calculated analogously using maternal plasma.</div></div><div><h3>Results</h3><div>PBDE congeners with the highest detection frequencies were maternal BDE-28 (42 %), BDE-47 (42 %), BDE-153 (100 %); and cord BDE-28 (50 %), BDE-47 (52 %), BDE-153 (95 %), BDE-154 (33 %). Maternal smoking was inversely associated with cord BDE-28 (−0.80 [−1.50, −0.09]). Higher paternal education was negatively associated with cord BDE-28 (−0.93 [−1.58, −0.27]), BDE-153 (−0.21 [−0.43, −0.005]), and BDE-154 (−4.34 [−8.00, −0.68]). High vegetable intake was inversely associated with cord BDE-154 (−3.99 [−7.76, −0.22]), while high meat intake was positively associated with total cord BFRs (0.42 [0.06, 0.78]), cord BDE-47 (0.67 [0.13, 1.21]), and maternal BDE-47 (0.77 [0.16, 1.37]).</div></div><div><h3>Conclusion</h3><div>PBDE levels were higher in cord than maternal samples but lower than in other European countries. Findings support maternal-to-child PBDE transfer and reveal associations with lifestyle, diet, and sociodemographic factors, including paternal variables-a notable gap in prior research.</div></div>\",\"PeriodicalId\":11539,\"journal\":{\"name\":\"Emerging Contaminants\",\"volume\":\"12 1\",\"pages\":\"Article 100596\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2026-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Emerging Contaminants\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405665025001301\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/11/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emerging Contaminants","FirstCategoryId":"1087","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405665025001301","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/11/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

人类接触阻燃剂，特别是多溴二苯醚，可在母体血浆中检测到，并与各种不良健康结果有关，但父母的生活方式和饮食对这些水平的影响仍知之甚少。目的首次在芬兰北部人群中监测母体和脐带血浆样本中的多溴二苯醚，并研究其与父母健康决定因素（特别是饮食摄入、环境暴露和生活方式因素）的关系。方法收集奥卢大学医院剖宫产术中102例NUGEN队列产妇的产妇血浆和脐带血浆样本。分析血浆样品中PBDE同系物（BDE-47、BDE-66、BDE-85、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183、BDE-209）、DBDPE和氯化阻燃剂（sDP、aDP）的含量，并进行脂质调整。脐带总BFRs以脐带血浆中所有同系物的总和计算，母体总BFRs以母体血浆类似地计算。结果spbde同系物检出率最高的为母体BDE-28（42%）、BDE-47（42%）、BDE-153 (100%)；脐带BDE-28 (50%), BDE-47 (52%), BDE-153 (95%), BDE-154（33%）。母亲吸烟与脐带BDE-28呈负相关（- 0.80[- 1.50,- 0.09]）。较高的父亲教育程度与脐带BDE-28（- 0.93[- 1.58, - 0.27]）、BDE-153（- 0.21[- 0.43, - 0.005]）和BDE-154（- 4.34[- 8.00, - 0.68]）呈负相关。高蔬菜摄入量与脐带BDE-154呈负相关（- 3.99[- 7.76,- 0.22]），而高肉类摄入量与脐带总bfr（0.42[0.06, 0.78]）、脐带BDE-47（0.67[0.13, 1.21]）和母体BDE-47（0.77[0.16, 1.37]）呈正相关。结论新生儿脐带中多溴二苯醚含量高于产妇，但低于欧洲其他国家。研究结果支持多溴二苯醚母婴转移，并揭示了与生活方式、饮食和社会人口因素（包括父亲变量）的关联——这是先前研究的显著差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Monitoring and assessing the association of polybrominated diphenyl ethers (PBDEs) and flame retardants (Dechlorane Plus and DBDPE) with parental lifestyle factors in a mother–child cohort of the Finnish population (NUGEN)

查看原文本刊更多论文

Background

Human exposure to flame retardants, particularly PBDEs, is detectable in maternal plasma and linked to various adverse health outcomes, but the influence of parental lifestyle and diet on these levels remains poorly understood.

Objective

To monitor PBDEs in maternal and cord plasma samples and examine their relationships with parental health determinants - specifically dietary intake, environmental exposure, and lifestyle factors-in a Northern Finland population for the first time.

Methods

Maternal and cord plasma samples from 102 NUGEN cohort pairs were collected during caesarean sections at Oulu University Hospital. Plasma samples were analysed for PBDE congeners (BDE-47, BDE-66, BDE-85, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, BDE-209), DBDPE, and chlorinated flame retardants (sDP, aDP), with lipid adjustment. Total cord BFRs were calculated as the sum of all congeners quantified in cord plasma, and total maternal BFRs were calculated analogously using maternal plasma.

Results

PBDE congeners with the highest detection frequencies were maternal BDE-28 (42 %), BDE-47 (42 %), BDE-153 (100 %); and cord BDE-28 (50 %), BDE-47 (52 %), BDE-153 (95 %), BDE-154 (33 %). Maternal smoking was inversely associated with cord BDE-28 (−0.80 [−1.50, −0.09]). Higher paternal education was negatively associated with cord BDE-28 (−0.93 [−1.58, −0.27]), BDE-153 (−0.21 [−0.43, −0.005]), and BDE-154 (−4.34 [−8.00, −0.68]). High vegetable intake was inversely associated with cord BDE-154 (−3.99 [−7.76, −0.22]), while high meat intake was positively associated with total cord BFRs (0.42 [0.06, 0.78]), cord BDE-47 (0.67 [0.13, 1.21]), and maternal BDE-47 (0.77 [0.16, 1.37]).

Conclusion

PBDE levels were higher in cord than maternal samples but lower than in other European countries. Findings support maternal-to-child PBDE transfer and reveal associations with lifestyle, diet, and sociodemographic factors, including paternal variables-a notable gap in prior research.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Emerging Contaminants Medicine-Public Health, Environmental and Occupational Health

CiteScore

10.00

自引率

6.70%

发文量

审稿时长

44 days

期刊介绍： Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.