揭示PANoptosis在急性肾损伤中的关键作用及其临床意义。

IF 5.9 2区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Translational Research Pub Date : 2025-10-01 Epub Date: 2025-11-11 DOI:10.1016/j.trsl.2025.11.002

Songyuan Yang , Zehua Ye , Sheng Zhao , Fan Cheng

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引用次数: 0

摘要

急性肾损伤（AKI）是一项重大的公共卫生挑战，其特点是发病率和死亡率高。PANoptosis是一个多方面的细胞死亡过程，涉及焦亡、凋亡和坏死凋亡之间复杂的相互作用。该机制通过PANoptosome复合物介导细胞死亡，该复合物结合了多种细胞死亡途径的成分。靶向PANoptosis治疗AKI的治疗潜力越来越有希望。在这篇综述中，我们探讨了AKI中PANoptosis的最新进展，并探讨了可能的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unraveling PANoptosis a key player in acute kidney injury and its clinical implications

Acute kidney injury (AKI) represents a significant public health challenge, marked by high rates of incidence and mortality. PANoptosis, a multifaceted process of cell death, involves complex interactions between pyroptosis, apoptosis, and necroptosis. This mechanism mediates cell death via the PANoptosome complex, which combines components from multiple cell death pathways. The therapeutic potential of targeting PANoptosis for AKI treatment is increasingly promising. In this review, we explore recent progress in the understanding of PANoptosis in AKI and examine possible therapeutic targets.

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来源期刊

Translational Research 医学-医学：内科

CiteScore

15.70

自引率

0.00%

发文量

195

审稿时长

14 days

期刊介绍： Translational Research (formerly The Journal of Laboratory and Clinical Medicine) delivers original investigations in the broad fields of laboratory, clinical, and public health research. Published monthly since 1915, it keeps readers up-to-date on significant biomedical research from all subspecialties of medicine.