st段抬高型心肌梗死患者入院时血浆脂肪酸水平与肾功能的关系。

IF 3.2

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2025-12-01 Epub Date: 2025-10-22 DOI:10.1016/j.plefa.2025.102712

Christa Meisinger , Timo Schmitz , Philip Raake , Jakob Linseisen

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引用次数: 0

摘要

背景：先前的研究表明多不饱和脂肪酸（PUFAs）与慢性肾脏疾病（肾小球滤过率[GFR] < 60 ml/min/1.73 m²）的发展有关，但到目前为止还没有关于急性心肌梗死（AMI）患者PUFAs与肾功能之间关系的研究。我们的目的是研究入院时血浆脂肪酸水平是否以及如何与急性st段抬高型心肌梗死（STEMI）患者的肾功能相关。方法：本研究基于2009年5月至2013年7月奥格斯堡大学医院收治的717例29至98岁STEMI患者的数据。在这些患者入院后立即采集的动脉血液样本中，通过高通量核磁共振波谱平台测量血浆脂肪酸组（Nightingale Health, Finland）。为了检查脂肪酸组（暴露）与肾功能（连续eGFR；结果）之间的关系，计算了线性回归模型。P值经fdr校正。结果：在多变量分析中，总PUFAs、总omega-6脂肪酸、亚油酸和二十二碳六烯酸（DHA）的浓度与入院时血清eGFR值呈正相关。这些发现得到了这些脂肪酸与总脂肪酸之间显著正相关关系的支持（除了DHA/总脂肪酸的比例）。虽然单不饱和脂肪酸（MUFAs）的浓度与eGFR无关，但MUFAs/总脂肪酸的比值与肾功能呈显著负相关。结论：PUFAs，特别是omega-6脂肪酸，似乎与AMI患者的肾功能有关。鉴于肾功能对冠心病/急性心肌梗死患者预后的重要性，有必要进一步研究干预措施，以尽量减少肾功能恶化，保护该患者组的肾功能。

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Admission plasma levels of fatty acids and kidney function in patients with ST-segment elevation myocardial infarction

Background

Prior studies suggested a link between polyunsaturated fatty acids (PUFAs) and the development of chronic kidney disease (glomerular filtration rate [GFR] < 60 ml/min/1.73 m²), but so far there are no studies on the association between PUFAs and kidney function in patients with acute myocardial infarction (AMI). We aimed to investigate whether and how plasma fatty acids levels at admission were associated with kidney function in patients with acute ST-elevation myocardial infarction (STEMI).

Methods

This study was based on data from 717 patients with STEMI aged 29 to 98 years admitted to the University Hospital Augsburg between May 2009 and July 2013. In arterial blood samples taken from these patients immediately after admission a panel of plasma fatty acids was measured by a high-throughput nuclear magnetic resonance spectroscopy platform (Nightingale Health, Finland). To examine the association between the fatty acid groups (exposure) and kidney function (continuous eGFR; outcome), linear regression models were calculated. P values were FDR-adjusted.

Results

In multivariable analyses the concentrations of total PUFAs, total omega-6 fatty acids, linoleic acid, and docosahexaenoic acid (DHA) were positively associated with serum eGFR values at admission. These findings were supported by a significantly positive association between these fatty acids in relation to total fatty acids (except for the ratio DHA/total fatty acids). While the concentration of monounsaturated fatty acids (MUFAs) was not associated with eGFR, a significantly inverse association was observed between the ratio MUFAs/total fatty acids and kidney function.

Conclusions

PUFAs, particularly omega-6 fatty acids, seem to be associated with kidney function in patients with AMI. Given the prognostic importance of renal function in coronary heart disease/AMI patients, further research on interventions to minimize worsening renal function and protect kidney function in this patient group is warranted.

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