Comment on "The Impact of Postmastectomy Radiation Therapy on Immediate Prepectoral Reconstruction with Polyurethane-Coated Implants".

This letter comments on the recent study by Salgarello et al. regarding the outcomes of polyurethane-coated implants in the setting of postmastectomy radiotherapy. We highlight the study's contributions while addressing methodological limitations such as sample size, lack of control group, potential selection bias, and the absence of patient-reported outcomes. We also propose future research directions including comparative studies with ADM, adjunctive therapies, and cost-effectiveness analyses. The letter underscores the importance of multidisciplinary approaches in breast reconstruction.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .