Cognitive Predictors of Functional Status Transitions Among Older Adults with Seven-Year Follow-Up: A Latent Transition Analysis.

Introduction: Preserving functional abilities is crucial for older adults to remain independent. Cognitive functions such as memory, orientation, and executive functions are vital for managing everyday activities. Despite rapid population aging, the differential impacts of various cognitive functions on functional transitions over time remain poorly understood. This study sought to identify longitudinal patterns of functional status transitions among older adults and examine how baseline cognitive predictors contribute to these transitions.

Methods: This study analyzed data from a nationally representative sample of 9,538 Chinese adults aged 60 and above, drawn from the China Health and Retirement Longitudinal Study. Latent transition analysis was employed to identify patterns of functional transitions from 2013 to 2020 and to evaluate the predictive utility of cognitive measures assessed in 2011.

Results: The analysis revealed four functional classes at both time points: Highly Functionally Independent, Mildly Functionally Dependent, Moderately IADL Dependent, and Severely Functionally Dependent. The Highly Functionally Independent and Severely Functionally Dependent classes showed high temporal stability, while individuals in the Mildly and Moderately Dependent classes were more likely to either experience improvement or decline. Using the Stable Functional Independence class as the reference group, the covariate-adjusted model identified higher baseline orientation as the most robust predictor. Specifically, better baseline orientation significantly reduced the likelihood of membership in either the Functional Improvement or Stable Functional Dependence classes. Better memory performance was also linked to a lower likelihood of being in the Functional Decline and Stable Functional Dependence classes. Additionally, higher executive functions performance was associated with a reduced likelihood of membership in the Functional Improvement class.

Conclusion: This study highlights the heterogeneity of functional transitions during the aging process. Within this cohort, orientation emerged as the most consistent protective factor against functional deterioration. The protective role of orientation is likely attributable not only to its fundamental importance for performing essential functional tasks, but also as a key early indicator of mild cognitive impairment and dementia. These findings underscore that distinct cognitive predictors can differentially influence trajectories of functional aging.